| Company Name: |
ChemeGen |
| Tel: |
18818260767 |
| Email: |
2625930290@qq.com |
1,4-Naphthalenedione, 2-[(3-methylbutyl)amino]- manufacturers
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| | 1,4-Naphthalenedione, 2-[(3-methylbutyl)amino]- Basic information |
| | 1,4-Naphthalenedione, 2-[(3-methylbutyl)amino]- Chemical Properties |
| Boiling point | 381.9±42.0 °C(Predicted) | | density | 1.13±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml,Ethanol: 20 mg/ml | | form | A crystalline solid | | pka | 2.37±0.20(Predicted) |
| | 1,4-Naphthalenedione, 2-[(3-methylbutyl)amino]- Usage And Synthesis |
| Uses | 2-(Isopentylamino)naphthalene-1,4-dione (compound 3d), a Vitamin K (HY-B2172) analogue, shows protection in Pentylenetetrazole (PTZ)-induced seizure model. 2-(Isopentylamino)naphthalene-1,4-dione significantly increases ATP levels in zebrafish as well as HT-22 cells. 2-(Isopentylamino)naphthalene-1,4-dione shows excellent permeability into the brain[1]. | | References | [1] Xiaoyang Li, et al. Discovery of the First Vitamin K Analogue as a Potential Treatment of Pharmacoresistant Seizures. J Med Chem. 2020 Jun 11;63(11):5865-5878. DOI:10.1021/acs.jmedchem.0c00168 |
| | 1,4-Naphthalenedione, 2-[(3-methylbutyl)amino]- Preparation Products And Raw materials |
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