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Benzoic acid, 3-[2-[(2-fluorophenyl)amino]-4-thiazolyl]- manufacturers
- NF-κΒ activator 1
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- $87.00
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2026-06-02
- CAS:2387524-59-4
- Purity: 99.58%
- Supply Ability: 10g
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| | Benzoic acid, 3-[2-[(2-fluorophenyl)amino]-4-thiazolyl]- Basic information |
| | Benzoic acid, 3-[2-[(2-fluorophenyl)amino]-4-thiazolyl]- Chemical Properties |
| Boiling point | 532.5±60.0 °C(Predicted) | | density | 1.427±0.06 g/cm3(Predicted) | | solubility | DMSO : 125 mg/mL (397.67 mM; Need ultrasonic) | | form | Solid | | pka | 3.84±0.10(Predicted) | | color | Light yellow to yellow |
| | Benzoic acid, 3-[2-[(2-fluorophenyl)amino]-4-thiazolyl]- Usage And Synthesis |
| Uses | NF-κΒ activator 1 (compound 32) is a potent NF-κΒ activator with an EC50 of 0.9 μM. NF-κΒ activator 1 induces superoxide dismutase (SOD)2 mRNA expression[1]. | | Biological Activity | NF-κβ activator 1 is a potent NF-κβ activator with an EC50 of 0.9 μM. NF-κβ activator 1 induces superoxide dismutase (SOD)2 mRNA expression[1].
NF-κβ activator 1 (compound 32) (1 μM; 6 hours) induces SOD2 mRNA expression in SH-SY5Y neuroblastoma cells[1]. | | IC 50 | NF-κB: 0.9 μM (EC50) | | References | [1]. Mathew B, et al. Structure-activity relationship (SAR) studies of N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (SRI-22819) as NF-B activators for the treatment of ALS [published online ahead of print, 2020 Oct 22]. Eur J Med Chem. 2020;112952. |
| | Benzoic acid, 3-[2-[(2-fluorophenyl)amino]-4-thiazolyl]- Preparation Products And Raw materials |
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