Benzoic acid, 4-[(1,5-dihydro-5-oxo-2H-[1]benzopyrano[3,4-c]pyridin-3(4H)-yl)carbonyl]-

Benzoic acid, 4-[(1,5-dihydro-5-oxo-2H-[1]benzopyrano[3,4-c]pyridin-3(4H)-yl)carbonyl]- Suppliers list

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Products Intro:	Product Name:DS44960156 CAS:2361327-08-2 Purity:99.13% Package:1mg;71USD\|5mg;172USD\|10mg;263USD

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Company Name:	Shanghai EFE Biological Technology Co., Ltd.
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Benzoic acid, 4-[(1,5-dihydro-5-oxo-2H-[1]benzopyrano[3,4-c]pyridin-3(4H)-yl)carbonyl]- manufacturers

Benzoic acid, 4-[(1,5-dihydro-5-oxo-2H-[1]benzopyrano[3,4-c]pyridin-3(4H)-yl)carbonyl]- Basic information

Product Name:	Benzoic acid, 4-[(1,5-dihydro-5-oxo-2H-[1]benzopyrano[3,4-c]pyridin-3(4H)-yl)carbonyl]-
Synonyms:	Benzoic acid, 4-[(1,5-dihydro-5-oxo-2H-[1]benzopyrano[3,4-c]pyridin-3(4H)-yl)carbonyl]-;4-[(1,5-dihydro-5-oxo-2H-[1]benzopyrano[3,4-c]pyridin-3(4H)-yl)carbonyl]-benzoic acid;DS44960156, 10 mM in DMSO;4-(5-oxo-1,5-dihydro-2H-[1]benzopyrano[3,4-c]pyridine-3(4H)-carbonyl)benzoic acid;4-(5-Oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzoic acid
CAS:	2361327-08-2
MF:	C20H15NO5
MW:	349.34
EINECS:
Product Categories:
Mol File:	2361327-08-2.mol

Benzoic acid, 4-[(1,5-dihydro-5-oxo-2H-[1]benzopyrano[3,4-c]pyridin-3(4H)-yl)carbonyl]- Chemical Properties

Boiling point	652.9±55.0 °C(Predicted)
density	1.47±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: soluble,Methanol: soluble
form	A crystalline solid
pka	3.86±0.10(Predicted)
color	White to off-white

Safety Information

MSDS Information

Benzoic acid, 4-[(1,5-dihydro-5-oxo-2H-[1]benzopyrano[3,4-c]pyridin-3(4H)-yl)carbonyl]- Usage And Synthesis

Uses	DS44960156 is a selective Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor, with IC50 values of 1.6 μM and >30 μM for MTHFD2 and MTHFD1, respectively[1].
Biological Activity	DS44960156 is an inhibitor of methylenetetrahydrofolate dehydrogenase 2 (MTHFD2; IC50 = 1.6 μM).1 It is selective for MTHFD2 over MTHFD1 (IC50 = >30 μM).
References	1.Kawai, J., Ota, M., Ohki, H., et al.Structure-based design and synthesis of an isozyme-selective MTHFD2 inhibitor with a tricyclic coumarin scaffoldACS Med. Chem. Lett.10(6)893-898(2019)

Benzoic acid, 4-[(1,5-dihydro-5-oxo-2H-[1]benzopyrano[3,4-c]pyridin-3(4H)-yl)carbonyl]- Preparation Products And Raw materials

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