8-羟基-1,3,6-萘三磺酸
| 中文名称 | 8-羟基-1,3,6-萘三磺酸 |
|---|---|
| 中文同义词 | 8-羟基-1,3,6-萘三磺酸;化合物Ζ-STAT;Ζ-STAT |CAS 3316-02-7;NVP-LCQ195 ,E2404 |
| 英文名称 | ζ-Stat |
| 英文同义词 | 3,6-Naphthalenetrisulfonicacid,8-hydroxy-1;ζ-Stat (ZETA-STAT);NSC37044;6-naphthalenetrisulfonicacid,8-hydroxy-3;8-hydroxynaphthalene-1,3,6-trisulphonic acid;8-hydroxynaphthalene-1,3,6-trisulfonic acid;8-hydroxy-1,3,6-naphthalenetrisulfonic acid;ZETA-STAT |
| CAS号 | 3316-02-7 |
| 分子式 | C10H8O10S3 |
| 分子量 | 384.35952 |
| EINECS号 | 2220085 |
| 相关类别 | |
| Mol文件 | 3316-02-7.mol |
| 结构式 |  |
8-羟基-1,3,6-萘三磺酸 性质
| 储存条件 | Store at -20°C |
|---|---|
| 形态 | 固体 |
| 颜色 | 浅棕色至棕色 |
| 水溶解性 | Water : 62.5 mg/mL (162.61 mM; Need ultrasonic) |
| EPA化学物质信息 | 1,3,6-Naphthalenetrisulfonic acid, 8-hydroxy- (3316-02-7) |
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aPKC-ζ 5 μM (IC 50 ) |
ζ-Stat (0.1-20 µM) shows only 13% inhibition on PKC-ι at 20 μM, but shows a significant inhibition on PKC-ζ as 51% at 5 μM level.
ζ-Stat (0.1-10 µM; 3 d) significantly decreases cell proliferation of SK-MEL-2 and MeWo upon increasing the concentrations.
ζ-Stat (7 or 10 µM; 24-72 h) and 5-FU in combination is able to decrease the viability of LoVo CRC cells by more than 75%.
ζ-Stat (5 µM; 3 d) shows a significant diminution of phosphorylated, total PKC-ζ, Bcl-2 and PARP levels, and increases Caspase-3 and cleaved-PARP levels in SK-MEL-2 and MeWo cells.
ζ-Stat (5 µM; 1-10 h) does not show significant cytotoxicity on MEL-F-NEO, SK-MEL-2 and MeWo cells.
Cell Proliferation Assay
| Cell Line: | MEL-F-NEO, SK-MEL-2 and MeWo cells |
| Concentration: | 0.1, 0.5, 1, 2.5, 5, 7.5, 10 µM |
| Incubation Time: | 3 days |
| Result: |
Decreased proliferation by 47.7% for 5 µM in SK-MEL-2 cells and by 50.6% for 5 µM in MeWo cells.
Showed significant inhibitions on MEL-F-NEO cells 19.3% (P ≤ 0.05) at 10 μM. |
Western Blot Analysis
| Cell Line: | SK-MEL-2 and MeWo cells |
| Concentration: | 5 µM |
| Incubation Time: | 3 days |
| Result: | Decreased phosphorylated and total PKC-ζ levels. |
安全信息
| TSCA | TSCA listed |
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