| Company Name: |
Henan Aochuang Chemical Co.,Ltd.
|
| Tel: |
+86-0371-63689365 +8618638391208 |
| Email: |
sales@aochuangchem.com |
| Products Intro: |
Product Name:ARV-471
CAS:2229711-08-2
Purity:98% Package:1KG;USD|10KG;USD|25KG;USD
|
| Company Name: |
Taizhou Zhongzhi Biotechnology Co., Ltd Gold
|
| Tel: |
13012344321 |
| Email: |
3995296515@qq.com |
| Products Intro: |
Product Name:Vepdegestrant (ARV-471)
CAS:2229711-08-2
Purity:98%+ Package:10g;100g;1kg;10kg
|
| Company Name: |
Beijing Yisiyan Technology Research Center
|
| Tel: |
010-56645598 13366904824 |
| Email: |
bjkaida@163.com |
| Products Intro: |
Product Name:ARV-471
CAS:2229711-08-2
Package:10mg/;25mg/;50mg/;100mg/;500mg/;10000mg/
|
| Company Name: |
ShangHai Caerulum Pharma Discovery Co., Ltd.
|
| Tel: |
18149758185 18149758185; |
| Email: |
sales-cpd@caerulumpharma.com |
| Products Intro: |
Product Name:ARV-471
CAS:2229711-08-2
Purity:98% Package:10mg;100mg;1g;10g;100g;1kg
|
ARV-471 manufacturers
- ARV-471
-
- $0.00 / 1KG
-
2025-04-04
- CAS:2229711-08-2
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1ton
|
| | ARV-471 Basic information |
| Product Name: | ARV-471 | | Synonyms: | (S)-3-(5-(4-((4-(4-((1R,2S)-6-hydroxy-2 -phenyl-1,2,3,4-tetrahydronaphthalen-1-
yl)phenyl)cyclohexyl)methyl)piperazin- 1-yl)-1-oxoisoindolin-2-yl)piperidine-2,
6-dione;2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-;3-(5-{4-[(1-{4-[(1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl]phenyl}piperidin-4-yl)methyl]piperazin-1-yl}-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione;Vepdegestrant Impurity 1 | | CAS: | 2229711-08-2 | | MF: | C45H49N5O4 | | MW: | 723.9 | | EINECS: | | | Product Categories: | | | Mol File: | 2229711-08-2.mol |  |
| | ARV-471 Chemical Properties |
| density | 1.275±0.06 g/cm3(Predicted) | | pka | 10.36±0.60(Predicted) | | InChIKey | TZZDVPMABRWKIZ-MFTLXVFQSA-N | | SMILES | N1C(=O)CCC(N2CC3=C(C2=O)C=CC(N2CCN(CC4CCN(C5=CC=C([C@@H]6C7=C(C=C(O)C=C7)CC[C@@H]6C6=CC=CC=C6)C=C5)CC4)CC2)=C3)C1=O |
| | ARV-471 Usage And Synthesis |
| Uses | (Rac)-Vepdegestrant is the isomer of Vepdegestrant (HY-138642). Vepdegestrant ((R)-Lavandulol) is an orally active PROTAC estrogen receptor degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a half-maximal degradation concentration (DC50) of about 2 nM[1]. | | References | [1] Lin X, et al. Targeting estrogen receptor α for degradation with PROTACs: A promising approach to overcome endocrine resistance. Eur J Med Chem. 2020;206:112689. DOI:10.1016/j.ejmech.2020.112689
[2] Hermida-Prado F, et al. Endocrine Therapy Synergizes with SMAC Mimetics to Potentiate Antigen Presentation and Tumor Regression in Hormone Receptor-Positive Breast Cancer. Cancer Res. 2023 Oct 2;83(19):3284-3304. DOI:10.1158/0008-5472.CAN-23-1711
[3] JJ Flanagan, et al. Abstract P5-04-18: ARV-471, an oral estrogen receptor PROTAC degrader for breast cancer. |
| | ARV-471 Preparation Products And Raw materials |
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