1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 11-(aminomethyl)-4-ethyl-8-fluoro-4-hydroxy-9-methyl-, (4S)-

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1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 11-(aminomethyl)-4-ethyl-8-fluoro-4-hydroxy-9-methyl-, (4S)- Suppliers list
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1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 11-(aminomethyl)-4-ethyl-8-fluoro-4-hydroxy-9-methyl-, (4S)- manufacturers
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 11-(aminomethyl)-4-ethyl-8-fluoro-4-hydroxy-9-methyl-, (4S)- Basic information
Product Name:1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 11-(aminomethyl)-4-ethyl-8-fluoro-4-hydroxy-9-methyl-, (4S)-
Synonyms:1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 11-(aminomethyl)-4-ethyl-8-fluoro-4-hydroxy-9-methyl-, (4S)-;Campathecin Impurity 37;7-Aminomethyl-10-methyl-11-fluoro camptothecin
CAS:2378616-23-8
MF:C22H20FN3O4
MW:409.41
EINECS:
Product Categories:
Mol File:2378616-23-8.mol
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 11-(aminomethyl)-4-ethyl-8-fluoro-4-hydroxy-9-methyl-, (4S)- Structure
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 11-(aminomethyl)-4-ethyl-8-fluoro-4-hydroxy-9-methyl-, (4S)- Chemical Properties
Boiling point 802.4±65.0 °C(Predicted)
density 1.51±0.1 g/cm3(Predicted)
pka11.19±0.20(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 11-(aminomethyl)-4-ethyl-8-fluoro-4-hydroxy-9-methyl-, (4S)- Usage And Synthesis
Uses7-Aminomethyl-10-methyl-11-fluoro camptothecin is a cytotoxin of MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin (HY-132158). 7-Aminomethyl-10-methyl-11-fluoro camptothecin can be used for the synthesis of camptothecin antibody-drug conjugate (ADC)[1].
References[1] Li W, et, al. Synthesis and Evaluation of Camptothecin Antibody-Drug Conjugates. ACS Med Chem Lett. 2019 Sep 6;10(10):1386-1392. DOI:10.1021/acsmedchemlett.9b00301
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 11-(aminomethyl)-4-ethyl-8-fluoro-4-hydroxy-9-methyl-, (4S)- Preparation Products And Raw materials
Tag:1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 11-(aminomethyl)-4-ethyl-8-fluoro-4-hydroxy-9-methyl-, (4S)-(2378616-23-8) Related Product Information
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