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| | Pygenic acid A Basic information |
| Product Name: | Pygenic acid A | | Synonyms: | (2alpha,3alpha)-2,3-Dihydroxy-urs-12-en-28-oic acid;Pygenic acid A;2α,3α-Dihydroxy-19β-methyl-30-noroleana-12-ene-28-oic acid;PUNICALAGINS A&B(P);2,3-Dihydroxy-12-ursen-28-oic acid;3-Epicorosolic acid;(2α,3α)-2,3-Dihydroxyurs- 12-en-28-oic acid | | CAS: | 52213-27-1 | | MF: | C30H48O4 | | MW: | 472.7 | | EINECS: | | | Product Categories: | Pentacyclic Triterpenes | | Mol File: | 52213-27-1.mol |  |
| | Pygenic acid A Chemical Properties |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | Powder |
| | Pygenic acid A Usage And Synthesis |
| Description | 3-Epicorosolic acid has a potent inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) induction.
3-Epicorosolic acid shows both potent α-glucosidase and protein tyrosine phosphatase 1B (PTP1B) inhibitory activities with IC50 values of 30.18 and 4.08 μg/ml respectively.
3. 3-Epicorosolic acid shows mixed type inhibition against PTP1B, while it shows uncompetitive inhibition against α-glucosidase; suggests that it has potential antidiabetic activity.
4. 3-Epicorosolic acid possesses the ability to inhibit the expression of one or more inflammatory genes induced by 12-O-tetradecanoylphorbol-13 acetate in mouse skin, it has potential anti-inflammatory activities as well as cancer chemopreventive activity. | | Uses | Pygenic acid A is a natural compound that can be found in Prunella vulgaris. Pygenic acid A induces apoptosis in metastatic breast cancer cells. Pygenic acid A can be used for the research of diabetes, inflammatory diseases, and cancers[1]. | | target | Immunology & Inflammation related | | References | [1] Ga-Eun Lim, et al. Pygenic Acid A (PA) Sensitizes Metastatic Breast Cancer Cells to Anoikis and Inhibits Metastasis In Vivo. Int J Mol Sci. 2020 Nov; 21(22): 8444. DOI:10.3390/ijms21228444 |
| | Pygenic acid A Preparation Products And Raw materials |
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