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| | 4-(4-Chlorophenyl)butanoic acid Basic information |
| Product Name: | 4-(4-Chlorophenyl)butanoic acid | | Synonyms: | 4-(4-Chlorophenyl)butanic acid;4-(4-chlorophenyl)butanoic acid(SALTDATA: FREE);Benzenebutanoic acid, 4-chloro-;4-Chlorobenzenebutanoic acid;-(4-Chlorophenyl)butanic acid;4-(4-CHLORO-PHENYL)-BUTYRIC ACID;4-(4-chlorophenyl)butanoic acid | | CAS: | 4619-18-5 | | MF: | C10H11ClO2 | | MW: | 198.65 | | EINECS: | | | Product Categories: | | | Mol File: | 4619-18-5.mol |  |
| | 4-(4-Chlorophenyl)butanoic acid Chemical Properties |
| Melting point | 55 °C | | Boiling point | 181-184 °C | | density | 1.227±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 4.74±0.10(Predicted) | | Appearance | White to light brown Solid |
| | 4-(4-Chlorophenyl)butanoic acid Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 4-(4-chlorophenyl)butyric acid from 3-(4-chlorobenzoyl)propionic acid: A mixture of 4-(4-chlorophenyl)-4-oxobutanoic acid (1 eq.), potassium hydroxide (KOH, 3 eq.), and hydrazine hydrate (2.2 eq.) in ethylene glycol was placed in a reaction flask and azeotropically refluxed for 5 hr at 120-130 °C. Subsequently, the reaction temperature was gradually increased to 180 °C and the reflux was continued at 190 °C for 3 hours. After completion of the reaction, the reaction mixture was cooled to 25 °C, diluted with water and poured into 2.5 N hydrochloric acid (HCl) solution for acidification, and white crystals were precipitated to give 4-(4-chlorophenyl)butyric acid in 89% yield. | | References | [1] Patent: US6410585, 2002, B1
[2] Journal of Medicinal Chemistry, 1982, vol. 25, # 8, p. 947 - 952
[3] Patent: US2005/165004, 2005, A1. Location in patent: Page/Page column 28
[4] Patent: WO2015/134973, 2015, A1. Location in patent: Page/Page column 97; 98
[5] Angewandte Chemie - International Edition, 2017, vol. 56, # 41, p. 12476 - 12480 |
| | 4-(4-Chlorophenyl)butanoic acid Preparation Products And Raw materials |
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