Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with N-[[5-[[5-fluoro-4-[[4-(2-propyn-1-yloxy)phenyl]amino]-2-pyrimidinyl]amino]-2-methylphenyl]sulfonyl]propanamide (1:1)

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Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with N-[[5-[[5-fluoro-4-[[4-(2-propyn-1-yloxy)phenyl]amino]-2-pyrimidinyl]amino]-2-methylphenyl]sulfonyl]propanamide (1:1) Suppliers list
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Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with N-[[5-[[5-fluoro-4-[[4-(2-propyn-1-yloxy)phenyl]amino]-2-pyrimidinyl]amino]-2-methylphenyl]sulfonyl]propanamide (1:1) manufacturers
Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with N-[[5-[[5-fluoro-4-[[4-(2-propyn-1-yloxy)phenyl]amino]-2-pyrimidinyl]amino]-2-methylphenyl]sulfonyl]propanamide (1:1) Basic information
Product Name:Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with N-[[5-[[5-fluoro-4-[[4-(2-propyn-1-yloxy)phenyl]amino]-2-pyrimidinyl]amino]-2-methylphenyl]sulfonyl]propanamide (1:1)
Synonyms:Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with N-[[5-[[5-fluoro-4-[[4-(2-propyn-1-yloxy)phenyl]amino]-2-pyrimidinyl]amino]-2-methylphenyl]sulfonyl]propanamide (1:1);R 348;R348;R-932348 choline;R932348 choline,R 932348 choline;R-348
CAS:1620142-65-5
MF:C28H35FN6O5S
MW:586.68
EINECS:
Product Categories:
Mol File:1620142-65-5.mol
Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with N-[[5-[[5-fluoro-4-[[4-(2-propyn-1-yloxy)phenyl]amino]-2-pyrimidinyl]amino]-2-methylphenyl]sulfonyl]propanamide (1:1) Structure
Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with N-[[5-[[5-fluoro-4-[[4-(2-propyn-1-yloxy)phenyl]amino]-2-pyrimidinyl]amino]-2-methylphenyl]sulfonyl]propanamide (1:1) Chemical Properties
Safety Information
MSDS Information
Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with N-[[5-[[5-fluoro-4-[[4-(2-propyn-1-yloxy)phenyl]amino]-2-pyrimidinyl]amino]-2-methylphenyl]sulfonyl]propanamide (1:1) Usage And Synthesis
UsesR-348 (R-932348) choline is a potent and orally active JAK3 and Syk inhibitor. R-348 reduces IFN-γ, IL-6, and IL-10 expression. R-348 effectively diminishes acute cardiac allograft rejection[1].
IC 50JAK3; IL-6; IL-10
References[1] Deuse T, et al. Novel immunosuppression: R348, a JAK3- and Syk-inhibitor attenuates acute cardiac allograft rejection. Transplantation. 2008 Mar 27;85(6):885-92. DOI:10.1097/TP.0b013e318166acc4
Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with N-[[5-[[5-fluoro-4-[[4-(2-propyn-1-yloxy)phenyl]amino]-2-pyrimidinyl]amino]-2-methylphenyl]sulfonyl]propanamide (1:1) Preparation Products And Raw materials
Tag:Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with N-[[5-[[5-fluoro-4-[[4-(2-propyn-1-yloxy)phenyl]amino]-2-pyrimidinyl]amino]-2-methylphenyl]sulfonyl]propanamide (1:1)(1620142-65-5) Related Product Information
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