Acetic acid, 2-[3-[1-[[2-(3,4-dichlorophenyl)acetyl]methylamino]-2-(1-pyrrolidinyl)ethyl]phenoxy]- manufacturers
- ICI 204448
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- $2380.00
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2026-05-11
- CAS:125190-72-9
- Purity:
- Supply Ability: 10g
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| | Acetic acid, 2-[3-[1-[[2-(3,4-dichlorophenyl)acetyl]methylamino]-2-(1-pyrrolidinyl)ethyl]phenoxy]- Basic information |
| | Acetic acid, 2-[3-[1-[[2-(3,4-dichlorophenyl)acetyl]methylamino]-2-(1-pyrrolidinyl)ethyl]phenoxy]- Chemical Properties |
| Boiling point | 638.9±55.0 °C(Predicted) | | density | 1.320±0.06 g/cm3(Predicted) | | pka | 3.14±0.10(Predicted) |
| | Acetic acid, 2-[3-[1-[[2-(3,4-dichlorophenyl)acetyl]methylamino]-2-(1-pyrrolidinyl)ethyl]phenoxy]- Usage And Synthesis |
| Description | ICI 204448 is a potent and peripherally selective κ-opioid agonist, with possible uses in the treatment of heart attack as well as anti-itching effects. | | Uses | ICI-204448 free acid is a κ-opioid agonist with limited access to the CNS, ICI-204448 free acid can displace the binding of the kappa-opioid ligand 3H-bremazocine from guinea pig cerebellum membranes[1]. | | Definition | ChEBI: 2-[3-[1-[[2-(3,4-dichlorophenyl)-1-oxoethyl]-methylamino]-2-(1-pyrrolidinyl)ethyl]phenoxy]acetic acid is a monocarboxylic acid. | | References | [1] J S Shaw, et, al. ICI 204448: a kappa-opioid agonist with limited access to the CNS. Br J Pharmacol. 1989, 96, 4. DOI:10.1111/j.1476-5381.1989.tb11911.x |
| | Acetic acid, 2-[3-[1-[[2-(3,4-dichlorophenyl)acetyl]methylamino]-2-(1-pyrrolidinyl)ethyl]phenoxy]- Preparation Products And Raw materials |
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