2-Oxa-5,6-dithia-9,14-diazapentadecanoic acid, 8-carboxy-15-[4-[[[(1S)-2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-1-methyl-2-oxoethyl]amino]carbonyl]-2-pyridinyl]-10,13-dioxo-, 1-[[5-[6-[5-[[(2,4-difluorophenyl)sulfonyl]amino]-6-methoxy-3-pyridinyl]-4-quinol

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2-Oxa-5,6-dithia-9,14-diazapentadecanoic acid, 8-carboxy-15-[4-[[[(1S)-2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-1-methyl-2-oxoethyl]amino]carbonyl]-2-pyridinyl]-10,13-dioxo-, 1-[[5-[6-[5-[[(2,4-difluorophenyl)sulfonyl]amino]-6-methoxy-3-pyridinyl]-4-quinolinyl]-2-pyridinyl]methyl] ester, (8R)- Basic information
Product Name:2-Oxa-5,6-dithia-9,14-diazapentadecanoic acid, 8-carboxy-15-[4-[[[(1S)-2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-1-methyl-2-oxoethyl]amino]carbonyl]-2-pyridinyl]-10,13-dioxo-, 1-[[5-[6-[5-[[(2,4-difluorophenyl)sulfonyl]amino]-6-methoxy-3-pyridinyl]-4-quinolinyl]-2-pyridinyl]methyl] ester, (8R)-
Synonyms:2-Oxa-5,6-dithia-9,14-diazapentadecanoic acid, 8-carboxy-15-[4-[[[(1S)-2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-1-methyl-2-oxoethyl]amino]carbonyl]-2-pyridinyl]-10,13-dioxo-, 1-[[5-[6-[5-[[(2,4-difluorophenyl)sulfonyl]amino]-6-methoxy-3-pyridinyl]-4-quinolinyl]-2-pyridinyl]methyl] ester, (8R)-;FAP-PI3KI1
CAS:2415941-98-7
MF:C52H48F4N10O12S3
MW:1177.19
EINECS:
Product Categories:
Mol File:2415941-98-7.mol
2-Oxa-5,6-dithia-9,14-diazapentadecanoic acid, 8-carboxy-15-[4-[[[(1S)-2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-1-methyl-2-oxoethyl]amino]carbonyl]-2-pyridinyl]-10,13-dioxo-, 1-[[5-[6-[5-[[(2,4-difluorophenyl)sulfonyl]amino]-6-methoxy-3-pyridinyl]-4-quinolinyl]-2-pyridinyl]methyl] ester, (8R)- Structure
2-Oxa-5,6-dithia-9,14-diazapentadecanoic acid, 8-carboxy-15-[4-[[[(1S)-2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-1-methyl-2-oxoethyl]amino]carbonyl]-2-pyridinyl]-10,13-dioxo-, 1-[[5-[6-[5-[[(2,4-difluorophenyl)sulfonyl]amino]-6-methoxy-3-pyridinyl]-4-quinolinyl]-2-pyridinyl]methyl] ester, (8R)- Chemical Properties
density 1.56±0.1 g/cm3(Predicted)
pka3.13±0.10(Predicted)
Safety Information
MSDS Information
2-Oxa-5,6-dithia-9,14-diazapentadecanoic acid, 8-carboxy-15-[4-[[[(1S)-2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-1-methyl-2-oxoethyl]amino]carbonyl]-2-pyridinyl]-10,13-dioxo-, 1-[[5-[6-[5-[[(2,4-difluorophenyl)sulfonyl]amino]-6-methoxy-3-pyridinyl]-4-quinolinyl]-2-pyridinyl]methyl] ester, (8R)- Usage And Synthesis
UsesFAP-PI3KI1 is a fibroblast-activated protein (FAP)-targeted PI3K inhibitor that selectively targets FAP-expressing human idiopathic pulmonary fibrosis (IPF) cells and effectively inhibits collagen synthesis and reduces collagen deposition[1].
References[1] Suraj U Hettiarachchi, et al. Targeted inhibition of PI3 kinase/mTOR specifically in fibrotic lung fibroblasts suppresses pulmonary fibrosis in experimental models. Sci Transl Med. 2020 Oct 28;12(567):eaay3724. DOI:10.1126/scitranslmed.aay3724
2-Oxa-5,6-dithia-9,14-diazapentadecanoic acid, 8-carboxy-15-[4-[[[(1S)-2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-1-methyl-2-oxoethyl]amino]carbonyl]-2-pyridinyl]-10,13-dioxo-, 1-[[5-[6-[5-[[(2,4-difluorophenyl)sulfonyl]amino]-6-methoxy-3-pyridinyl]-4-quinolinyl]-2-pyridinyl]methyl] ester, (8R)- Preparation Products And Raw materials
Tag:2-Oxa-5,6-dithia-9,14-diazapentadecanoic acid, 8-carboxy-15-[4-[[[(1S)-2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-1-methyl-2-oxoethyl]amino]carbonyl]-2-pyridinyl]-10,13-dioxo-, 1-[[5-[6-[5-[[(2,4-difluorophenyl)sulfonyl]amino]-6-methoxy-3-pyridinyl]-4-quinolinyl]-2-pyridinyl]methyl] ester, (8R)-(2415941-98-7) Related Product Information
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