- 4-Morpholinoaniline
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- $1.00
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2019-07-06
- CAS:2524-67-6
- Min. Order: 1KG
- Purity: 95%-99.99%
- Supply Ability: 1kg-10MT
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| | 4-Morpholinoaniline Basic information |
| | 4-Morpholinoaniline Chemical Properties |
| Melting point | 132-135 °C(lit.) | | Boiling point | 310.47°C (rough estimate) | | density | 1.0777 (rough estimate) | | refractive index | 1.5250 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Soluble in chloroform, ethyl acetate. | | pka | 6.72±0.40(Predicted) | | form | Crystalline Powder | | color | Purple to brown | | BRN | 150957 | | InChI | InChI=1S/C10H14N2O/c11-9-1-3-10(4-2-9)12-5-7-13-8-6-12/h1-4H,5-8,11H2 | | InChIKey | PHNDZBFLOPIMSM-UHFFFAOYSA-N | | SMILES | C1(N)=CC=C(N2CCOCC2)C=C1 | | CAS DataBase Reference | 2524-67-6(CAS DataBase Reference) | | EPA Substance Registry System | 4-(4-Morpholino)aniline (2524-67-6) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/37/38-20/21/22 | | Safety Statements | 26-37/39-36/37/39-22 | | RIDADR | UN2811 | | WGK Germany | 3 | | Hazard Note | Irritant | | TSCA | TSCA listed | | HazardClass | 6.1 | | HS Code | 29349990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 4-Morpholinoaniline Usage And Synthesis |
| Chemical Properties | PURPLE TO BROWN CRYSTALLINE POWDER | | Uses | 4-Morpholinoaniline is a morpholine derivative used in the preparation of central nervous system (CNS) active agents. 4-Morpholinoaniline is also one of the primary aromatic amines used in the colour
developing process in photographs. | | Uses | 4-(4-Morpholinyl)aniline is used in the preparation of central nervous system (CNS) active agents, also used in the color developing process in photographs. | | Synthesis | The general procedure for the synthesis of 4-(4-morpholinyl)aniline from 4-(4-nitrophenyl)morpholine was as follows: referring to the method of Example 20, 4-(4-nitrophenyl)morpholine (10.3 g, 49.5 mmol; purchased from Lancaster Synthesis) was suspended in methanol (130 mL) and a methanolic solution of 2 M ammonia (70 mL). 1 mL of water and 5% palladium carbon catalyst (100 mg) were added. The mixture was placed in a Paar hydrogenation unit and hydrogenated at 50 psi hydrogen pressure for 1 hour. Upon completion of the reaction, the reaction mixture was allowed to cool to room temperature, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure. The resulting crude product was purified by solvent recrystallization from a mixture of ethyl acetate/hexane to give 4-(4-morpholinyl)aniline as a light purple solid (6.2 g, 70% yield, melting point 132-133 °C). The product was analyzed by GC/MS (EI, M+) and showed a molecular ion peak m/z=178. | | References | [1] Applied Organometallic Chemistry, 2018, vol. 32, # 1,
[2] Chemistry - An Asian Journal, 2017, vol. 12, # 7, p. 785 - 791
[3] Patent: EP2949647, 2015, A1. Location in patent: Paragraph 0120
[4] European Journal of Medicinal Chemistry, 2016, vol. 124, p. 896 - 905
[5] Patent: US2013/45977, 2013, A1. Location in patent: Paragraph 0215; 0216; 0217; 0218 |
| | 4-Morpholinoaniline Preparation Products And Raw materials |
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