1-Piperazineacetamide, 4-(2,3-dimethylphenyl)-N-(2-ethoxyphenyl)- manufacturers
- PPZ2
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- $1520.00
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2026-07-15
- CAS:896203-18-2
- Purity:
- Supply Ability: 10g
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| | 1-Piperazineacetamide, 4-(2,3-dimethylphenyl)-N-(2-ethoxyphenyl)- Basic information |
| | 1-Piperazineacetamide, 4-(2,3-dimethylphenyl)-N-(2-ethoxyphenyl)- Chemical Properties |
| Boiling point | 556.0±50.0 °C(Predicted) | | density | 1.132±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 5mg/mL, clear (warmed) | | pka | 14.02±0.70(Predicted) | | form | powder | | color | white to beige |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | 1-Piperazineacetamide, 4-(2,3-dimethylphenyl)-N-(2-ethoxyphenyl)- Usage And Synthesis |
| Description | PPZ2 is a novel activator of DAG-activated TRPC3/TRPC6/TRPC7 channels. | | Uses | PPZ2 is a diacylglycerol (DAG)-activated TRPC3/TRPC6/TRPC7 channel activator with activity in promoting neuronal development and survival. PPZ2 activates recombinant TRPC3/TRPC6/TRPC7 channels in a dose-dependent manner without affecting other TRPC channels. PPZ2 elicits cation currents and calcium ion (Ca(2+)) influx in cultured central neurons. PPZ2 is able to induce BDNF-like neurite outgrowth and neuroprotection, an effect that disappears after TRPC3/TRPC6/TRPC7 knockdown or inhibition. PPZ2 also increases the activation of the calcium-dependent transcription factor cAMP response element binding protein. The effects of PPZ2 suggest that calcium signaling mediated by activation of DAG-activated TRPC channels plays an important role in its neurotrophic effects[1]. | | References | [1] Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds |
| | 1-Piperazineacetamide, 4-(2,3-dimethylphenyl)-N-(2-ethoxyphenyl)- Preparation Products And Raw materials |
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