GS-441524 tris-isobutyryl ester manufacturers
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| | GS-441524 tris-isobutyryl ester Basic information |
| | GS-441524 tris-isobutyryl ester Chemical Properties |
| density | 1.37±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml | | form | A crystalline solid | | pka | 4.11±0.30(Predicted) |
| | GS-441524 tris-isobutyryl ester Usage And Synthesis |
| Uses | (S)-GS-621763 is the S-enantiomer of GS-621763 (HY-145119). GS-621763 is an orally active prodrug form of GS-443902 (HY-126303) that inhibits SARS-CoV-2[1]. | | Biological Activity | GS-441524 tris-isobutyryl ester is a prodrug form of the antiviral nucleoside analog and remdesivir metabolite GS-441524 .1 It reduces the cytopathic effect of respiratory syncytial virus (RSV) in infected HEp-2 cells with an EC50 value of 0.26 μM. | | References | 1.Mackman, R.L., Hui, H.C., Perron, M., et al.Prodrugs of a 1’-CN-4-aza-7,9-dideazaadenosine C-nucleoside leading to the discovery of remdesivir (GS-5734) as a potent inhibitor of respiratory syncytial virus with efficacy in the african green monkey model of RSVJ. Med. Chem.64(8)5001-5017(2021) |
| | GS-441524 tris-isobutyryl ester Preparation Products And Raw materials |
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