化合物 CBP-IN-1
| 中文名称 | 化合物 CBP-IN-1 |
|---|---|
| 中文同义词 | 1-(3-(7-(二氟甲基)-6-(1-甲基-1H-吡唑-4-基)-3,4-二氢喹啉-1(2H)-基)-1-(哌啶-4-基)-1,4,6,7-四氢-5H-吡唑并[4,3-c]吡啶-5-基)乙酮 |
| 英文名称 | 1-(3-(7-(difluoromethyl)-6-(1-melhyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-1-(piperidin-4-yl)-6.7- dihydro-1 H-pyrazolo[4,3-c]pyridin-5(4H)-yl)ethanone |
| 英文同义词 | 1-(3-(7-(difluoromethyl)-6-(1-melhyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-1-(piperidin-4-yl)-6.7- dihydro-1 H-pyrazolo[4,3-c]pyridin-5(4H)-yl)ethanone;Ethanone, 1-[3-[7-(difluoromethyl)-3,4-dihydro-6-(1-methyl-1H-pyrazol-4-yl)-1(2H)-quinolinyl]-1,4,6,7-tetrahydro-1-(4-piperidinyl)-5H-pyrazolo[4,3-c]pyridin-5-yl]-;1-(3-(7-(Difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-1-(piperidin-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one;CBP inhibitor (compound 12) |
| CAS号 | 1936431-44-5 |
| 分子式 | C27H33F2N7O |
| 分子量 | 509.61 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1936431-44-5.mol |
| 结构式 |  |
化合物 CBP-IN-1 性质
| 沸点 | 788.2±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.43±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 9.83±0.10(Predicted) |
CBP-IN-1 (compound 12) 是一种有效的 CBP 抑制剂，IC50 为 1.5 nM。 CBP-IN-1 还抑制 CBP BRET 和 BRD4(1)，IC50 值分别为 690 和 3100 nM。