Benzoic acid, 2-hydroxy-, 2-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazide

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Benzoic acid, 2-hydroxy-, 2-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazide Basic information
Product Name:Benzoic acid, 2-hydroxy-, 2-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazide
Synonyms:Benzoic acid, 2-hydroxy-, 2-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazide;WAY-358024;2-hydroxy-N'-(2-oxo-2,3-dihydro-1H-indol-3-ylidene)benzohydrazide;GSK-3β inhibitor 26;2-Hydroxy-N'-(2-oxoindolin-3-ylidene)benzohydrazide
CAS:70169-39-0
MF:C15H11N3O3
MW:281.27
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Mol File:70169-39-0.mol
Benzoic acid, 2-hydroxy-, 2-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazide Structure
Benzoic acid, 2-hydroxy-, 2-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazide Chemical Properties
Melting point >250 °C
density 1.44±0.1 g/cm3(Predicted)
pka8.26±0.30(Predicted)
Safety Information
MSDS Information
Benzoic acid, 2-hydroxy-, 2-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazide Usage And Synthesis
UsesGSK-3β inhibitor 26 (Compound D14) is a GSK-3β inhibitor with an IC50 of 18.23 μM. GSK-3β inhibitor 26 can be used in the research of cancer, inflammation and neurodegenerative diseases[1].
IC 50GSK-3β: 18.23 μM (IC50)
References[1] Dou X, et al. Discovery of new GSK-3β inhibitors through structure-based virtual screening. Bioorg Med Chem Lett. 2018 Jan 15;28(2):160-166. DOI:10.1016/j.bmcl.2017.11.036
Benzoic acid, 2-hydroxy-, 2-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazide Preparation Products And Raw materials
Tag:Benzoic acid, 2-hydroxy-, 2-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazide(70169-39-0) Related Product Information
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