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| | SPC-3649 Basic information |
| | SPC-3649 Chemical Properties |
| storage temp. | Store at -20°C, stored under nitrogen | | form | Solid | | color | Off-white to light yellow | | Water Solubility | Water : 100 mg/mL (20.13 mM; Need ultrasonic) | | Sequence | RNA, (P-thio)((2'-O,4'-C-methylene)m5C-dC-(2'-O,4'-C-methylene)A-dT-dT-(2'-O,4'-C-methylene)G-(2'-O,4'-C-methylene)m5U-dC-dA-(2'-O,4'-C-methylene)m5C-dA-(2'-O,4'-C-methylene)m5C-dT-(2'-O,4'-C-methylene)m5C-(2'-O,4'-C-methylene)m5C) |
| | SPC-3649 Usage And Synthesis |
| Uses | Miravirsen (SPC-3649) is a potent miR-122 inhibitor and inhibits the biogenesis of miR-122. Miravirsen is a 15-nucleotide locked nucleic acid-modified phosphorothioate antisense oligonucleotide. Miravirsen inhibits HCV replication. Miravirsen can be used in research of HCV infection[1][2]. | | in vivo | Miravirsen (SPC-3649; 2.5-25 mg/kg; i.v.; daily, for 3 d) inhibits miR-122 activity in mice[2]. | Animal Model: | NMRI female mice (27 g)[2] | | Dosage: | 2.5, 6.25, 12.5, and 25 mg/kg | | Administration: | Intravenous injection; daily, for 3 days | | Result: | Inhibited miR-122 activity in a dose-dependent manner. |
| | References | [1] Luca F R Gebert, et al. Miravirsen (SPC3649) can inhibit the biogenesis of miR-122. Nucleic Acids Res. 2014 Jan;42(1):609-21. DOI:10.1093/nar/gkt852
[2] Elmén J, et, al. Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver. Nucleic Acids Res. 2008 Mar;36(4):1153-62. DOI:10.1093/nar/gkm1113 |
| | SPC-3649 Preparation Products And Raw materials |
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