| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
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info@bocsci.com |
| Products Intro: |
Product Name:24(S),25-Epoxy cholesterol
CAS:77058-74-3
Purity:>=95% Remarks:Reach out to us for more information about custom solutions.
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| Company Name: |
Shanghai Aladdin Bio-Chem Technology Co.,LTD
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| Tel: |
400-6206333 13167063860 |
| Email: |
anhua.mao@aladdin-e.com |
| Products Intro: |
Product Name:24(S),25-epoxycholesterol
CAS:77058-74-3
Purity:98% Package:1mg/RMB 2574.90;5mg/RMB 10299.90
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| | 24(S),25-Epoxycholesterol (not deuterated) Basic information |
| Product Name: | 24(S),25-Epoxycholesterol (not deuterated) | | Synonyms: | 24(S),25-Epoxycholesterol (not deuterated);(24S)-24,25-Epoxycholest-5-en-3β-ol;(24S)-24,25-Epoxycholesterol;24S,25-EpoxyC;(24S)-24,25-Epoxycholestero;24(S);24(S),25-EPOXYCHOLESTEROL;24(S);25-EPOXYCHOLESTEROL;25-epoxycholesterol | | CAS: | 77058-74-3 | | MF: | C27H44O2 | | MW: | 400.64 | | EINECS: | | | Product Categories: | | | Mol File: | 77058-74-3.mol |  |
| | 24(S),25-Epoxycholesterol (not deuterated) Chemical Properties |
| Melting point | 156-157 °C | | Boiling point | 496.4±18.0 °C(predicted) | | density | 1.05 | | storage temp. | -20°C | | solubility | Soluble in DMSO (up to 30 mg/ml). | | pka | 15.03±0.70(predicted) | | form | White solid. | | color | White | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
| | 24(S),25-Epoxycholesterol (not deuterated) Usage And Synthesis |
| Description | 24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain. It activates liver X receptors (LXRs) in the developing ventral midbrain to induce stem cell differentiation into dopaminergic neurons. 24(S),25-epoxy Cholesterol inhibits IL-6 production and degranulation of bone marrow-derived murine mast cells that express LXRβ. It inhibits the conversion of desmosterol to cholesterol by 3β-hydroxysterol Δ24-reductase (DHCR24/Seladin-1) in CHO-7 and SRD-1 cells when used at a concentration of 2.5 μM. | | Uses | (24S)-24,25-Epoxycholesterol is a derivative of 4β-Hydroxy Cholesterol (H917980), a metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential ligand for the nuclear receptor LXR and also a new endogenous CYP3A marker. | | Definition | ChEBI: A 3beta-hydroxy steroid that is desmosterol in which the double bond at position 24-25 has been oxidised to the corresponding epoxide (the 24S diastereoisomer). It is an oxysterol agonist of the liver X receptor. | | in vivo | 24S,25-Epoxycholesterol (5 mM, icv) enhances the mDA neurogenesis, limits the neurodegeneration in CYP46A1-overexpressing mice midbrain[4]. | Animal Model: | GGPP induced mDA neurogenesis defect in CYP46A1 overexpressing CD-1 mice[4] | | Dosage: | 5 mM | | Administration: | icv, 1 μL, single dosage | | Result: | Increased levels of mDA neurons, blocked the GGPP induced decrease of double EdU and TH cells. |
| | References | [1] AJAY CHAWLA. Nuclear Receptors and Lipid Physiology: Opening the X-Files[J]. Science, 2001, 294 5548. DOI:10.1126/science.294.5548.1866
[2] BROWN A J. 24(S),25-Epoxycholesterol: A messenger for cholesterol homeostasis[J]. International Journal of Biochemistry & Cell Biology, 2009, 41 4: Pages 744-747. DOI:10.1016/j.biocel.2008.05.029
[3] SPYRIDON THEOFILOPOULOS. Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis[J]. Nature chemical biology, 2012, 9 2: 126-133. DOI:10.1038/nchembio.1156 |
| | 24(S),25-Epoxycholesterol (not deuterated) Preparation Products And Raw materials |
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