Acetic acid, 2-[3-[[3'-[[[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]amino]carbonyl]-5'-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4'-methyl[1,1'-biphenyl]-4-yl]oxy]propoxy]-

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Acetic acid, 2-[3-[[3'-[[[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]amino]carbonyl]-5'-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4'-methyl[1,1'-biphenyl]-4-yl]oxy]propoxy]- Basic information
Product Name:Acetic acid, 2-[3-[[3'-[[[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]amino]carbonyl]-5'-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4'-methyl[1,1'-biphenyl]-4-yl]oxy]propoxy]-
Synonyms:Acetic acid, 2-[3-[[3'-[[[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]amino]carbonyl]-5'-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4'-methyl[1,1'-biphenyl]-4-yl]oxy]propoxy]-;Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH
CAS:2750350-39-9
MF:C34H43N3O7
MW:605.72
EINECS:
Product Categories:
Mol File:2750350-39-9.mol
Acetic acid, 2-[3-[[3'-[[[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]amino]carbonyl]-5'-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4'-methyl[1,1'-biphenyl]-4-yl]oxy]propoxy]- Structure
Acetic acid, 2-[3-[[3'-[[[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]amino]carbonyl]-5'-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4'-methyl[1,1'-biphenyl]-4-yl]oxy]propoxy]- Chemical Properties
Boiling point 831.0±65.0 °C(Predicted)
density 1+-.0.06 g/cm3(Predicted)
storage temp. 4°C, away from moisture
solubility DMSO : ≥ 160 mg/mL (264.15 mM)
form Solid
pka3.47±0.10(Predicted)
color Yellow to brown
Safety Information
MSDS Information
Acetic acid, 2-[3-[[3'-[[[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]amino]carbonyl]-5'-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4'-methyl[1,1'-biphenyl]-4-yl]oxy]propoxy]- Usage And Synthesis
UsesTazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b) incorporates a ligand for EZH2, and a PROTAC linker, which recruit E3 ligases. Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b) can be used for the research of lymphoma[1].
IC 50EZH2
References[1] Tu Y, et al. Design, Synthesis, and Evaluation of VHL-Based EZH2 Degraders to Enhance Therapeutic Activity against Lymphoma. J Med Chem. 2021 Jul 22;64(14):10167-10184. DOI:10.1021/acs.jmedchem.1c00460
Acetic acid, 2-[3-[[3'-[[[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]amino]carbonyl]-5'-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4'-methyl[1,1'-biphenyl]-4-yl]oxy]propoxy]- Preparation Products And Raw materials
Tag:Acetic acid, 2-[3-[[3'-[[[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]amino]carbonyl]-5'-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4'-methyl[1,1'-biphenyl]-4-yl]oxy]propoxy]-(2750350-39-9) Related Product Information
EPZ015666 GSK-3326595 UNC-0642 DS-3201 MRTX-1719 SGC0946