1,4-Oxazepin-5(2H)-one, 4-[3-[[2-[[2-ethyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]propyl]tetrahydro- manufacturers
- DCC-3116
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- $66.00
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2026-08-30
- CAS:2543673-19-2
- Purity: 98.55%
- Supply Ability: 10g
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| | 1,4-Oxazepin-5(2H)-one, 4-[3-[[2-[[2-ethyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]propyl]tetrahydro- Basic information |
| | 1,4-Oxazepin-5(2H)-one, 4-[3-[[2-[[2-ethyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]propyl]tetrahydro- Chemical Properties |
| Boiling point | 736.6±70.0 °C(Predicted) | | density | 1.266±0.06 g/cm3(Predicted) | | pka | 7.87±0.42(Predicted) | | form | Solid | | color | Light brown to brown | | InChIKey | CNBTYICEJGEABG-UHFFFAOYSA-N | | SMILES | O1CCC(=O)N(CCCNC2C(C(F)(F)F)=CN=C(NC3=CC=C(N4CCN(C)CC4)C=C3CC)N=2)CC1 |
| | 1,4-Oxazepin-5(2H)-one, 4-[3-[[2-[[2-ethyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]propyl]tetrahydro- Usage And Synthesis |
| Uses | DCC-3116 is an orally active ULK1/2 inhibitor. DCC-3116 can promote autophagy in lung cancer cells by inhibiting KRASG12C signaling, thereby inhibiting the proliferation of lung cancer cells and exerting anti-cancer effects[1]. | | in vivo | DCC-3116 (3 or 30 mg/kg/day for 56 days, p.o. and p.i.) alone or in combination with Sotorasib (HY-114277) can inhibit tumor growth in mouse models of NSCLC lung cancer[1].
| Animal Model: | mouse models of NSCLC lung cancer (adult mice were initiated between 6-8 weeks of age) [1] | | Dosage: | 3 or 30 mg/kg/day for 56 days | | Administration: | p.o. and p.i | | Result: | Inhibited mice tumor growth and improved mice survival rate, while significantly reducing mice body weight (>20%). |
| | IC 50 | ULK1; ULK2; KRas G12C | | References | [1] Ghazi PC, et al. Inhibition of ULK1/2 and KRAS G12C controls tumor growth in preclinical models of lung cancer. bioRxiv [Preprint]. 2024 Feb 8:2024.02.06.579200. DOI:10.1101/2024.02.06.579200 |
| | 1,4-Oxazepin-5(2H)-one, 4-[3-[[2-[[2-ethyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]propyl]tetrahydro- Preparation Products And Raw materials |
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