Cinnoline, 8-chloro-4-[4-(3-chloro-5-methoxyphenyl)-1-piperazinyl]-

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Cinnoline, 8-chloro-4-[4-(3-chloro-5-methoxyphenyl)-1-piperazinyl]- Suppliers list
Company Name: Guangzhou Younan Technology Co., Ltd  
Tel: 020-82000279 18988941452
Email: YN_research@163.com
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

Cinnoline, 8-chloro-4-[4-(3-chloro-5-methoxyphenyl)-1-piperazinyl]- manufacturers
Cinnoline, 8-chloro-4-[4-(3-chloro-5-methoxyphenyl)-1-piperazinyl]- Basic information
Product Name:Cinnoline, 8-chloro-4-[4-(3-chloro-5-methoxyphenyl)-1-piperazinyl]-
Synonyms:Cinnoline, 8-chloro-4-[4-(3-chloro-5-methoxyphenyl)-1-piperazinyl]-;Anticancer agent 82
CAS:2319587-80-7
MF:C19H18Cl2N4O
MW:389.28
EINECS:
Product Categories:
Mol File:2319587-80-7.mol
Cinnoline, 8-chloro-4-[4-(3-chloro-5-methoxyphenyl)-1-piperazinyl]- Structure
Cinnoline, 8-chloro-4-[4-(3-chloro-5-methoxyphenyl)-1-piperazinyl]- Chemical Properties
Boiling point 606.3±65.0 °C(Predicted)
density 1.363±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
form Solid
pka5.56±0.10(Predicted)
color Light yellow to orange
Safety Information
MSDS Information
Cinnoline, 8-chloro-4-[4-(3-chloro-5-methoxyphenyl)-1-piperazinyl]- Usage And Synthesis
UsesVimentin-IN-1 is a FiVe1 derivative, an orally active and selective anticancer agent. FiVe1 binds type IIIintermediate filament proteinvimentin(VIM), to induce hyperphosphorylationof Ser56, resulting selective disruption of mitosis and multinucleation in transformed VIM-expressing mesenchymal cancer cells. Vimentin-IN-1 shows better oral bioavailability andpharmacokineticprofiles than FiVe1[1].
in vivo

Vimentin-IN-1 (compound 4e) (10 mg/kg; p.o.; single dose) shows better oral pharmacokinetic properties than Five1[1].
Pharmacokinetic properties of Vimentin-IN-1 in mice[1]

RouteDose (mg/kg)AUC0-last (ng·h/mL)AUC0-inf (ng·h/mL)T1/2 (h)Tmax (h)Tlast (h)Cmax (ng/mL)
4ePO10371.33534.334.680.678154.67
4eIP1208.33211.330.590.254197.00
Five1PO25309.78339.214.570.518110.43
References[1] Martínez-Pea F, et al. Synthesis and biological evaluation of novel FiVe1 derivatives as potent and selective agents for the treatment of mesenchymal cancers. Eur J Med Chem. 2022 Nov 15;242:114638. DOI:10.1016/j.ejmech.2022.114638
Cinnoline, 8-chloro-4-[4-(3-chloro-5-methoxyphenyl)-1-piperazinyl]- Preparation Products And Raw materials
Tag:Cinnoline, 8-chloro-4-[4-(3-chloro-5-methoxyphenyl)-1-piperazinyl]-(2319587-80-7) Related Product Information
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