2,4(1H,3H)-Pyrimidinedione, 1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-5-iodo-

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2,4(1H,3H)-Pyrimidinedione, 1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-5-iodo- Suppliers list
Company Name: NewCan Biotech Limited
Tel: +86-571-86912261 19975279805
Email: sales@newcanbio.com
Products Intro: Product Name:L-I-OddU
CAS:207920-87-4
Purity:97% Package:mgs,gs,kgs
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:L-I-OddU
CAS:207920-87-4
Package:25mg/RMB 14900;50mg/RMB 19420;100mg/RMB 24625
Company Name: Shanghai meikai technology co., ltd  
Tel: 021-68689288 15300790979
Email: info@mkbio.com.cn
Products Intro: Product Name:1-((2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)-5-iodopyrimidine-2,4(1H,3H)-dione
CAS:207920-87-4
Purity:98% Package:100mg;250mg;1g
2,4(1H,3H)-Pyrimidinedione, 1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-5-iodo- Basic information
Product Name:2,4(1H,3H)-Pyrimidinedione, 1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-5-iodo-
Synonyms:2,4(1H,3H)-Pyrimidinedione, 1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-5-iodo-;L-I-OddU;1-((2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)-5-iodopyrimidine-2,4(1H,3H)-dione
CAS:207920-87-4
MF:C8H9IN2O5
MW:340.07
EINECS:
Product Categories:
Mol File:207920-87-4.mol
2,4(1H,3H)-Pyrimidinedione, 1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-5-iodo- Structure
2,4(1H,3H)-Pyrimidinedione, 1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-5-iodo- Chemical Properties
Melting point 223 °C (decomp)
density 2.17±0.1 g/cm3(Predicted)
pka7.83±0.10(Predicted)
Safety Information
MSDS Information
2,4(1H,3H)-Pyrimidinedione, 1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-5-iodo- Usage And Synthesis
UsesL-I-OddU, a L-5'-halo- dioxolane nucleoside analogue, is a potent and selective anti-Epstein-Barr virus (EBV) agent with an EC50 value of 0.03μM. L-I-OddU has low cytotoxicity with a CC50 value of 1000 nM. L-I-OddU has antiviral activity by suppressing replicative EBV DNA and viral protein synthesis[1][2].
References[1] Kira T, et, al. Anti-Epstein-Barr virus (EBV) activity of beta-L-5-iododioxolane uracil is dependent on EBV thymidine kinase. Antimicrob Agents Chemother. 2000 Dec;44(12):3278-84. DOI:10.1128/AAC.44.12.3278-3284.2000
[2] Focher F, et, al. Antivirals at the mirror: the lack of stereospecificity of some viral and human enzymes offers novel opportunities in antiviral drug development. Curr Drug Targets Infect Disord. 2003 Mar;3(1):41-53. DOI:10.2174/1568005033342163
2,4(1H,3H)-Pyrimidinedione, 1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-5-iodo- Preparation Products And Raw materials
Tag:2,4(1H,3H)-Pyrimidinedione, 1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-5-iodo-(207920-87-4) Related Product Information