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| | CAROVERINEHYDROCHLORIDE Basic information |
| Product Name: | CAROVERINEHYDROCHLORIDE | | Synonyms: | CAROVERINEHYDROCHLORIDE;1-(2-diethylaminoethyl)-3-[(4-methoxyphenyl)methyl]quinoxalin-2-one;1-[2-(Diethylamino)ethyl]-3-[(4-methoxyphenyl)methyl]-2(1H)-quinoxalinone monohydrochloride;1-(2-Diethylamino)ethyl-3-((4-methoxyphenyl)methyl)-2(1H)-quinoxalinone hydrochloride;1-Diethylaminoethyl-3-(p-methoxybenzyl)-2-quinoxaone hydrochloride;2(1H)-Quinoxalinone, 1-(2-diethylamino)ethyl-3-(4-methoxybenzyl)-, hydrochloride;p 201-1;1-[2-(diethylamino)ethyl]-3-[(4-methoxyphenyl)methyl]quinoxalin-2-one,hydrochloride | | CAS: | 55750-05-5 | | MF: | C22H27N3O2 | | MW: | 0 | | EINECS: | | | Product Categories: | APIs | | Mol File: | 55750-05-5.mol |  |
| | CAROVERINEHYDROCHLORIDE Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: >10mg/mL | | form | solid | | color | White to off-white |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 |
| | CAROVERINEHYDROCHLORIDE Usage And Synthesis |
| Uses | Caroverine hydrochloride is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. Caroverine hydrochloride is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action. Caroverine hydrochloride can be used for the research of inner ear tinnitus[1][2][3]. | | in vivo | Caroverine (1.44 mg/rat; s.c; 1.0 mL/h for 72 h) attenuates impulse noise-induced hearing loss in the rat[4]. | Animal Model: | Sprague-Dawley rats of either sex (250-300 g) received impulse noise exposure[4] | | Dosage: | 1.44 mg/rat | | Administration: | 20 mg/mL; s.c. 1.0 mL/h for 72 h | | Result: | Significantly protected the cochlea against impulse noise trauma. |
| | References | [1] Chen Z, et, al. Pharmacokinetics of caroverine in the inner ear and its effects on cochlear function after systemic and local administrations in Guinea pigs. Audiol Neurootol. Jan-Feb 2003;8(1):49-56. DOI:10.1159/000067893
[2] Denk DM, et, al. Caroverine in tinnitus treatment. A placebo-controlled blind study. Acta Otolaryngol. 1997 Nov;117(6):825-30. DOI:10.3109/00016489709114208
[3] Ishida Y, et, al. Vasorelaxant action of caroverine fumarate (a quinoxaline derivative), a calcium-blocking agent. Br J Pharmacol. 1980;71(1):343-8. DOI:10.1111/j.1476-5381.1980.tb10945.x
[4] Duan M, et, al. Low-dose, long-term caroverine administration attenuates impulse noise-induced hearing loss in the rat. Acta Otolaryngol. 2006 Dec;126(11):1140-7. DOI:10.1080/00016480500540519 |
| | CAROVERINEHYDROCHLORIDE Preparation Products And Raw materials |
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