cyclo(Arg-Arg-Arg-Arg-Nal-Nal-Nal)

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cyclo(Arg-Arg-Arg-Arg-Nal-Nal-Nal) Basic information
Product Name:cyclo(Arg-Arg-Arg-Arg-Nal-Nal-Nal)
Synonyms:c[Arg-Arg-Arg-Arg-Nal-Nal-Nal];cyclo(Arg-Arg-Arg-Arg-Nal-Nal-Nal)
CAS:2619854-01-0
MF:C63H81N19O7
MW:1216.44
EINECS:
Product Categories:
Mol File:2619854-01-0.mol
cyclo(Arg-Arg-Arg-Arg-Nal-Nal-Nal) Structure
cyclo(Arg-Arg-Arg-Arg-Nal-Nal-Nal) Chemical Properties
density 1.43±0.1 g/cm3(Predicted)
pka12.87±0.70(Predicted)
Sequencec[Arg-Arg-Arg-Arg-{D-2-Nal}-{D-2-Nal}-{D-2-Nal}]
Safety Information
MSDS Information
cyclo(Arg-Arg-Arg-Arg-Nal-Nal-Nal) Usage And Synthesis
Usesc[Arg-Arg-Arg-Arg-Nal-Nal-Nal] (Compound 9C) shows broad-spectrum activity against drug-resistant Gram-positive and Gram-negative bacteria, with MICs of 3.1, 3,1, 12.5, and 25 μg/mL for MRSA (ATCC BAA-1556), S. aureus (ATCC 29213), P. aeruginosa (ATCC 27883), and E. coli (ATCC 25922), respectively[1].
References[1] Sandeep Lohan, et al. Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties. J Med Chem. 2022 Jan 13;65(1):665-687. DOI:10.1021/acs.jmedchem.1c01782
cyclo(Arg-Arg-Arg-Arg-Nal-Nal-Nal) Preparation Products And Raw materials
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