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1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one manufacturers
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| | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one Basic information |
| Product Name: | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one | | Synonyms: | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one;Uridine, 5,6-dihydro-;Uridine Impurity 28（5,6-Dihydrouridine）;6-Dihydrouridine;5,6-Dihydrouridine RNA-modified nucleoside D;1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)dihydropyrimidine-2,4(1H,3H)-dione;5,6-Dihydrouridine, 10 mM in DMSO;dihydrouridine | | CAS: | 5627-05-4 | | MF: | C9H14N2O6 | | MW: | 246.22 | | EINECS: | | | Product Categories: | | | Mol File: | 5627-05-4.mol | ![1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one Structure](CAS/GIF/5627-05-4.gif) |
| | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one Chemical Properties |
| density | 1.614±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 16 mg/ml; DMSO: 10 mg/ml; PBS (pH 7.2): 5 mg/ml | | form | A crystalline solid | | pka | 12.40±0.20(Predicted) | | color | White to off-white | | PH | ~11 | | λmax | 208 (in H2O) | | Stability: | Hygroscopic |
| | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one Usage And Synthesis |
| Uses | 5,6-Dihydrouridine is an intermediate used in the synthesis of 3,4,5,6-Tetrahydrouridine (>80%) (T310250), which is a derivative of Uridine (U829910). Tetrahydrouridine (THU) is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA. | | Definition | ChEBI: The uridine derivative obtained by formal hydrogenation of the endocyclic double bond in the uracil ring. | | IC 50 | Human Endogenous Metabolite |
| | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one Preparation Products And Raw materials |
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