- 5-Aminoindole
-
- $0.00 / 1kg
-
2025-04-04
- CAS:5192-03-0
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1Ton
- 5-Aminoindole
-
- $15.00 / 1KG
-
2021-08-12
- CAS:5192-03-0
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- 5-Aminoindole in stock Factory
-
- $1.00 / 1KG
-
2020-06-02
- CAS:5192-03-0
- Min. Order: 1KG
- Purity: TOP 3 Factory in China
- Supply Ability: Top 3 largest production capacity Factory
|
| | 5-Aminoindole Basic information |
| | 5-Aminoindole Chemical Properties |
| Melting point | 131-133 °C (dec.) (lit.) | | Boiling point | 190 °C / 6mmHg | | density | 1.1083 (rough estimate) | | refractive index | 1.6013 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMSO, Methanol | | pka | 17.39±0.30(Predicted) | | form | Crystalline Powder | | color | Off-white to gray-brown | | Water Solubility | insoluble | | Sensitive | Air & Light Sensitive | | BRN | 112348 | | InChI | 1S/C8H8N2/c9-7-1-2-8-6(5-7)3-4-10-8/h1-5,10H,9H2 | | InChIKey | ZCBIFHNDZBSCEP-UHFFFAOYSA-N | | SMILES | Nc1ccc2[nH]ccc2c1 | | CAS DataBase Reference | 5192-03-0(CAS DataBase Reference) | | NIST Chemistry Reference | 5-Aminoindole(5192-03-0) | | EPA Substance Registry System | 5-Aminoindole (5192-03-0) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-36/37/38-68 | | Safety Statements | 26-45-36/37 | | WGK Germany | 3 | | F | 10 | | Hazard Note | Irritant | | TSCA | TSCA listed | | HazardClass | AIR SENSITIVE, IRRITANT-HARMFUL, KEEP COLD | | HS Code | 29339990 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Dermal
Acute Tox. 4 Oral
Aquatic Acute 1
Eye Irrit. 2 |
| | 5-Aminoindole Usage And Synthesis |
| Chemical Properties | Grey Crystals | | Uses | Reactant for preparation of:
- Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP
- Cytotoxic and antimitotic agents
- Insulin-like growth factor 1 receptor inhibitors
- Antitumoral agents
- Factor Xa inhibitor
- Potential antivascular agents
- Gli1-mediated transcription in the Hedgehog pathway
- Inhibitors of receptor tyrosine kinase with antiangiogenic effects
- PKCθ inhibitors
- HIV protease inhibitors
| | Uses | 5-Aminoindole functions as a ligand for hydrophobic charge induction chromatography. A reagent for synthetic elaboration. | | Definition | ChEBI: An indolamine carrying an amino group at position 5. | | Synthesis | In Example 1, 5-nitroindole was substituted for m-nitroacetophenone as a raw material, maintaining a molar ratio of 1:1. The reaction was carried out at 80 °C for 24 h under hydrogen pressure of 4.0 MPa. Other conditions were consistent with Example 1, and 5-aminoindole was finally obtained in 98% yield. This was done as follows: 16.44 mg (0.04 mmol) of silver 4,4'-dimethoxy-2,2'-bipyridine, 11.22 mg (0.1 mmol) of potassium tert-butanolate and 1 ml of 1,4-dioxane solution were added to an autoclave. After thorough stirring, 165.15 mg (1 mmol) of m-nitroacetophenone was added and the mixture was stirred and reacted at 80 °C for 8 hours. Upon completion of the reaction, the reaction solution was extracted with deionized water and dichloromethane and the organic phase was collected. The organic phase was dried over anhydrous Na2SO4 and then subjected to filtration, rotary evaporation and chromatographic separation to afford 3-acetanilide as a yellow solid in 96% yield. | | References | [1] Synthetic Communications, 2012, vol. 42, # 2, p. 213 - 222
[2] Bioorganic and Medicinal Chemistry, 2000, vol. 8, # 6, p. 1415 - 1422
[3] Organic Letters, 2014, vol. 16, # 1, p. 98 - 101
[4] ACS Catalysis, 2015, vol. 5, # 6, p. 3457 - 3462
[5] Patent: CN106748834, 2017, A. Location in patent: Paragraph 0016; 0029; 0032 |
| | 5-Aminoindole Preparation Products And Raw materials |
|