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| | USP5-IN-1 Basic information |
| Product Name: | USP5-IN-1 | | Synonyms: | USP5-IN-1;(5-((4-(4-Chlorophenyl)piperidin-1-yl)sulfonyl)picolinoyl)glycine;Glycine, N-[[5-[[4-(4-chlorophenyl)-1-piperidinyl]sulfonyl]-2-pyridinyl]carbonyl]- | | CAS: | 2851040-81-6 | | MF: | C19H20ClN3O5S | | MW: | 437.9 | | EINECS: | | | Product Categories: | | | Mol File: | 2851040-81-6.mol |  |
| | USP5-IN-1 Chemical Properties |
| density | 1.432±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | pka | 3.43±0.10(predicted) | | form | Solid | | color | White to light yellow |
| | USP5-IN-1 Usage And Synthesis |
| Uses | USP5-IN-1 (compound 64), a potent deubiquitinase USP5 inhibitor, binds to the USP5 ZnF-UBD with a KD of 2.8 μM. USP5-IN-1 is selective over nine proteins containing structurally similar ZnF-UBD domains. USP5-IN-1 inhibits the USP5 catalytic cleavage of a di-ubiquitin substrate[1]. | | References | [1] Mann MK, et al. Structure-Activity Relationship of USP5 Inhibitors [published correction appears in J Med Chem. 2022 Jan 13;65(1):889]. J Med Chem. 2021;64(20):15017-15036. DOI:10.1021/acs.jmedchem.1c00889 |
| | USP5-IN-1 Preparation Products And Raw materials |
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