L-Phenylalanine, L-alanyl-L-valyl-L-threonyl-L-α-aspartyl-L-histidyl-L-prolyl-L-α-aspartyl-L-arginyl-L-leucyl-L-tryptophyl-L-alanyl-L-tryptophyl-L-α-glutamyl-L-lysyl-

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L-Phenylalanine, L-alanyl-L-valyl-L-threonyl-L-α-aspartyl-L-histidyl-L-prolyl-L-α-aspartyl-L-arginyl-L-leucyl-L-tryptophyl-L-alanyl-L-tryptophyl-L-α-glutamyl-L-lysyl- Basic information
Product Name:L-Phenylalanine, L-alanyl-L-valyl-L-threonyl-L-α-aspartyl-L-histidyl-L-prolyl-L-α-aspartyl-L-arginyl-L-leucyl-L-tryptophyl-L-alanyl-L-tryptophyl-L-α-glutamyl-L-lysyl-
Synonyms:L-Phenylalanine, L-alanyl-L-valyl-L-threonyl-L-α-aspartyl-L-histidyl-L-prolyl-L-α-aspartyl-L-arginyl-L-leucyl-L-tryptophyl-L-alanyl-L-tryptophyl-L-α-glutamyl-L-lysyl-;TCL1(10-24)
CAS:835655-37-3
MF:C88H123N23O23
MW:1871.06
EINECS:
Product Categories:
Mol File:835655-37-3.mol
L-Phenylalanine, L-alanyl-L-valyl-L-threonyl-L-α-aspartyl-L-histidyl-L-prolyl-L-α-aspartyl-L-arginyl-L-leucyl-L-tryptophyl-L-alanyl-L-tryptophyl-L-α-glutamyl-L-lysyl- Structure
L-Phenylalanine, L-alanyl-L-valyl-L-threonyl-L-α-aspartyl-L-histidyl-L-prolyl-L-α-aspartyl-L-arginyl-L-leucyl-L-tryptophyl-L-alanyl-L-tryptophyl-L-α-glutamyl-L-lysyl- Chemical Properties
density 1.49±0.1 g/cm3(Predicted)
pka3.49±0.10(Predicted)
SequenceAla-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe
Safety Information
MSDS Information
L-Phenylalanine, L-alanyl-L-valyl-L-threonyl-L-α-aspartyl-L-histidyl-L-prolyl-L-α-aspartyl-L-arginyl-L-leucyl-L-tryptophyl-L-alanyl-L-tryptophyl-L-α-glutamyl-L-lysyl- Usage And Synthesis
UsesTCL1(10-24) is a encompassing the betaA strand of human TCL1. TCL1(10-24) is a Akt inhibitor. TCL1(10-24) interacts with the Akt PH domain prevented phosphoinositide binding and hence inhibits membrane translocation and activation of Akt. TCL1(10-24) inhibits cellular proliferation and anti-apoptosis. TCL1(10-24) has tumor growth in vivo[1].
References[1] Makoto Hiromura, et al. Inhibition of Akt kinase activity by a peptide spanning the betaA strand of the proto-oncogene TCL1. J Biol Chem. 2004 Dec 17;279(51):53407-18. DOI:10.1074/jbc.M403775200
L-Phenylalanine, L-alanyl-L-valyl-L-threonyl-L-α-aspartyl-L-histidyl-L-prolyl-L-α-aspartyl-L-arginyl-L-leucyl-L-tryptophyl-L-alanyl-L-tryptophyl-L-α-glutamyl-L-lysyl- Preparation Products And Raw materials
Tag:L-Phenylalanine, L-alanyl-L-valyl-L-threonyl-L-α-aspartyl-L-histidyl-L-prolyl-L-α-aspartyl-L-arginyl-L-leucyl-L-tryptophyl-L-alanyl-L-tryptophyl-L-α-glutamyl-L-lysyl-(835655-37-3) Related Product Information
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