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| Product Name: | SEX HORMONE BINDING GLOBULIN | | Synonyms: | ANTI-SHBG (N-TERM) antibody produced in rabbit;HTEBG;HSHBG;TESTOSTERONE-ESTRADIOL BINDING GLOBULIN;TESTOSTERONE-ESTRADIOL BINDING GLOBULIN, HUMAN;SEX HORMONE BINDING GLOBULIN;SHBG, HUMAN;Sex Hormone-Binding Globulin from human serum | | CAS: | | | MF: | | | MW: | 612.74 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![SEX HORMONE BINDING GLOBULIN Structure]() |
| | SEX HORMONE BINDING GLOBULIN Chemical Properties |
| storage temp. | −20°C | | form | buffered aqueous glycerol solution | | biological source | rabbit |
| Hazard Codes | B | | WGK Germany | 1 | | Storage Class | 12 - Non Combustible Liquids |
| | SEX HORMONE BINDING GLOBULIN Usage And Synthesis |
| Uses | Sex hormone binding globulin (SHBG) from human serum has been used as a spiked sample in radioimmunoassay. It may also be used to study the effects of hydroxylated estrogen metabolites (2-OH-E2 and 4-OH-E2) on the mRNA and protein expression of SHBG in MCF-7 human breast cancer cell line. | | General Description | Sex hormone binding globulin (SHBG) is secreted by the liver. It is also expressed in the endometrium, ovary and testis. SHBG is composed of 402 amino acids and the gene encoding it is localized on human chromosome 17p12–p13. | | Biochem/physiol Actions | Sex hormone binding globulin (SHBG) is a dimeric plasma glycoprotein with high affinity for the gonadal steroids, testosterone and estradiol. It regulates the availability of sex steroid hormones and limits their access to target cells. SHBG also inhibits estradiol-induced proliferation of breast cancer cells. Alterations in the expression of the protein have been linked to male infertility. | | Description | SHBG Human Recombinant produced in CHO cells is a single, glycosylated, polypeptide chain containing a total of 428 amino acids, having a molecular mass of 46.79kDa (calculated), the SHBG is fused to a 6 a.a C-terminal His tag and also includes a myc-epitope.
The Human SHBG is purified by proprietary chromatographic techniques. | | Source | CHO cells | | Background | Sex-hormone-binding globulin (SHBG) is a beta-globulin which specifically binds steroid hormones; it is involved in the transport of sex steroids in plasma. The main site of SHBG synthesis is assumed to be the hepatocytes. The production of SHBG is regulated by androgen/estrogen balance, thyroid hormones, and dietary factors, among others. The concentration of SHBG is a key factor regulating their distribution between protein-bound and free states. SHBG concentration determination is primarily significant in the evaluation of mild disorders of androgen metabolism and it allows detection of women with hirsutism who are likely to react to estrogen therapy. Testosterone/SHBG-ratios correlate well with both measured and calculated values for free testosterone thus aid to distinguish between subjects with excessive androgen activity and normal individuals. SHBG gene polymorphisms are linked with polycystic ovary syndrome and type 2 diabetes mellitus. |
| | SEX HORMONE BINDING GLOBULIN Preparation Products And Raw materials |
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