5-Pyrimidinecarbonitrile, 2-[2-[(3-hydroxyphenyl)methylene]hydrazinyl]-4-(4-methoxyphenyl)-6-(4-morpholinyl)-

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5-Pyrimidinecarbonitrile, 2-[2-[(3-hydroxyphenyl)methylene]hydrazinyl]-4-(4-methoxyphenyl)-6-(4-morpholinyl)- Suppliers list
Company Name: Tianjin Kailiqi Biotechnology Co., Ltd.  
Tel: 15076683720
Email: klq@cw-bio.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

5-Pyrimidinecarbonitrile, 2-[2-[(3-hydroxyphenyl)methylene]hydrazinyl]-4-(4-methoxyphenyl)-6-(4-morpholinyl)- manufacturers

  • PI3K-IN-34
  • PI3K-IN-34 pictures
  • $2500.00
  • 2026-05-11
  • CAS:2458163-94-3
  • Purity:
  • Supply Ability: 10g
5-Pyrimidinecarbonitrile, 2-[2-[(3-hydroxyphenyl)methylene]hydrazinyl]-4-(4-methoxyphenyl)-6-(4-morpholinyl)- Basic information
Product Name:5-Pyrimidinecarbonitrile, 2-[2-[(3-hydroxyphenyl)methylene]hydrazinyl]-4-(4-methoxyphenyl)-6-(4-morpholinyl)-
Synonyms:5-Pyrimidinecarbonitrile, 2-[2-[(3-hydroxyphenyl)methylene]hydrazinyl]-4-(4-methoxyphenyl)-6-(4-morpholinyl)-;PI3K-IN-34
CAS:2458163-94-3
MF:C23H22N6O3
MW:430.46
EINECS:
Product Categories:
Mol File:2458163-94-3.mol
5-Pyrimidinecarbonitrile, 2-[2-[(3-hydroxyphenyl)methylene]hydrazinyl]-4-(4-methoxyphenyl)-6-(4-morpholinyl)- Structure
5-Pyrimidinecarbonitrile, 2-[2-[(3-hydroxyphenyl)methylene]hydrazinyl]-4-(4-methoxyphenyl)-6-(4-morpholinyl)- Chemical Properties
Boiling point 752.6±70.0 °C(Predicted)
density 1.32±0.1 g/cm3(Predicted)
pka9.16±0.10(Predicted)
Safety Information
MSDS Information
5-Pyrimidinecarbonitrile, 2-[2-[(3-hydroxyphenyl)methylene]hydrazinyl]-4-(4-methoxyphenyl)-6-(4-morpholinyl)- Usage And Synthesis
UsesPI3K-IN-34 (Compound 6g) is a highly selective PI3K inhibitor with IC50 values of 11.73, 6.09 and 11.18 μM for PI3K-α、PI3K-β and PI3K-δ , respectively. PI3K-IN-34 arrests cell cycle at G2/M phase and induces apoptosis. PI3K-IN-34 can be used in leukemia research[1].
IC 50PI3Kα: 8.43 μM (IC50); PI3Kβ: 15.84 μM (IC50); PI3Kδ: 30.62 μM (IC50)
References[1] Helwa AA, et al. Novel antiproliferative agents bearing morpholinopyrimidine scaffold as PI3K inhibitors and apoptosis inducers; design, synthesis and molecular docking. Bioorg Chem. 2020 Sep;102:104051. DOI:10.1016/j.bioorg.2020.104051
5-Pyrimidinecarbonitrile, 2-[2-[(3-hydroxyphenyl)methylene]hydrazinyl]-4-(4-methoxyphenyl)-6-(4-morpholinyl)- Preparation Products And Raw materials
Tag:5-Pyrimidinecarbonitrile, 2-[2-[(3-hydroxyphenyl)methylene]hydrazinyl]-4-(4-methoxyphenyl)-6-(4-morpholinyl)-(2458163-94-3) Related Product Information
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