2-Quinazolinecarboxamide, N-methyl-4-[[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]amino]-

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2-Quinazolinecarboxamide, N-methyl-4-[[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]amino]- Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:VEGFR-2-IN-26
CAS:2439096-06-5
Package:100mg/RMB 17500;25mg/RMB 10600;50mg/RMB 13800
2-Quinazolinecarboxamide, N-methyl-4-[[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]amino]- Basic information
Product Name:2-Quinazolinecarboxamide, N-methyl-4-[[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]amino]-
Synonyms:2-Quinazolinecarboxamide, N-methyl-4-[[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]amino]-;VEGFR-2-IN-26
CAS:2439096-06-5
MF:C24H19F3N6O2
MW:480.44
EINECS:
Product Categories:
Mol File:2439096-06-5.mol
2-Quinazolinecarboxamide, N-methyl-4-[[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]amino]- Structure
2-Quinazolinecarboxamide, N-methyl-4-[[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]amino]- Chemical Properties
density 1.454±0.06 g/cm3(Predicted)
pka10.99±0.46(Predicted)
Safety Information
MSDS Information
2-Quinazolinecarboxamide, N-methyl-4-[[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]amino]- Usage And Synthesis
UsesVEGFR-2-IN-26 (compound 5h) is a highly potent VEGFR-2 inhibitor with an IC50 value of 15.5 nM. VEGFR-2-IN-26 has good antiproliferative activity against the leukemic, non-small lung, CNS, ovarian, renal, prostate and breast cancer cells[1].
IC 50VEGFR-2: 15.5 nM (IC50)
References[1] Hadi SRAE, et al. Scaffold hopping and redesign approaches for quinazoline based urea derivatives as potent VEGFR-2 inhibitors. Bioorg Chem. 2020 Aug;101:103961. DOI:10.1016/j.bioorg.2020.103961
2-Quinazolinecarboxamide, N-methyl-4-[[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]amino]- Preparation Products And Raw materials
Tag:2-Quinazolinecarboxamide, N-methyl-4-[[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]amino]-(2439096-06-5) Related Product Information