4-((2-chlorophenyl)amino)-6-((6-methylpyridin-2-yl)amino)nicotinamide

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4-((2-chlorophenyl)amino)-6-((6-methylpyridin-2-yl)amino)nicotinamide Basic information
Product Name:4-((2-chlorophenyl)amino)-6-((6-methylpyridin-2-yl)amino)nicotinamide
Synonyms:4-((2-chlorophenyl)amino)-6-((6-methylpyridin-2-yl)amino)nicotinamide;3-Pyridinecarboxamide, 4-[(2-chlorophenyl)amino]-6-[(6-methyl-2-pyridinyl)amino]-;4-[(2-chlorophenyl)amino]-6-[(6-methylpyridin-2-yl)amino]pyridine-3-carboxamide;CEE321
CAS:2098545-89-0
MF:C18H16ClN5O
MW:353.81
EINECS:
Product Categories:
Mol File:2098545-89-0.mol
4-((2-chlorophenyl)amino)-6-((6-methylpyridin-2-yl)amino)nicotinamide Structure
4-((2-chlorophenyl)amino)-6-((6-methylpyridin-2-yl)amino)nicotinamide Chemical Properties
Boiling point 508.0±50.0 °C(Predicted)
density 1.388±0.06 g/cm3(Predicted)
pka14.82±0.50(Predicted)
Safety Information
MSDS Information
4-((2-chlorophenyl)amino)-6-((6-methylpyridin-2-yl)amino)nicotinamide Usage And Synthesis
UsesCEE321 is a potent pan-JAK inhibitor with an IC50 value of 54 nM. CEE321 potently inhibits biomarkers associated with atopic dermatitis[1].
References[1] Thoma G, et al. Discovery and Characterization of the Topical Soft JAK Inhibitor CEE321 for Atopic Dermatitis. J Med Chem. 2023 Feb 9;66(3):2161-2168. DOI:10.1021/acs.jmedchem.2c01977
4-((2-chlorophenyl)amino)-6-((6-methylpyridin-2-yl)amino)nicotinamide Preparation Products And Raw materials
Tag:4-((2-chlorophenyl)amino)-6-((6-methylpyridin-2-yl)amino)nicotinamide(2098545-89-0) Related Product Information
2-Propenoic acid, 3-[2,6-dichloro-4-[[[4-[3-(2,2-dimethyl-1-propoxypropyl)-2-methoxyphenyl]-2-thiazolyl]amino]carbonyl]phenyl]-2-methyl-, (2E)- Ruxolitinib NA gamma-Glu-Cys trifluoroacetate salt Phlorizin JAK1 Protein, HUMAN (P. PASTORIS, HIS)