Benzoic acid, 4-(4-quinolinylamino)-, 2-(4-pyridinylmethylene)hydrazide

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Benzoic acid, 4-(4-quinolinylamino)-, 2-(4-pyridinylmethylene)hydrazide manufacturers

  • 4-PQBH
  • 4-PQBH pictures
  • $69.00
  • 2026-07-16
  • CAS:2243355-51-1
  • Purity: 99.08%
  • Supply Ability: 10g
Benzoic acid, 4-(4-quinolinylamino)-, 2-(4-pyridinylmethylene)hydrazide Basic information
Product Name:Benzoic acid, 4-(4-quinolinylamino)-, 2-(4-pyridinylmethylene)hydrazide
Synonyms:Benzoic acid, 4-(4-quinolinylamino)-, 2-(4-pyridinylmethylene)hydrazide;4-PQBH
CAS:2243355-51-1
MF:C22H17N5O
MW:367.4
EINECS:
Product Categories:
Mol File:2243355-51-1.mol
Benzoic acid, 4-(4-quinolinylamino)-, 2-(4-pyridinylmethylene)hydrazide Structure
Benzoic acid, 4-(4-quinolinylamino)-, 2-(4-pyridinylmethylene)hydrazide Chemical Properties
density 1.25±0.1 g/cm3(Predicted)
pka12.06±0.46(Predicted)
form Solid
color Off-white to light yellow
Safety Information
MSDS Information
Benzoic acid, 4-(4-quinolinylamino)-, 2-(4-pyridinylmethylene)hydrazide Usage And Synthesis
Uses4-PQBH is a potent Nur77 binder (KD=1.17 μM). 4-PQBH extensively induces caspase-independent cytoplasmic vacuolization and paraptosis through Nur77-mediated ER stress and autophagy. 4-PQBH can be used for cancer research[1].
IC 50Nur77/NR4A1
References[1] Baicun Li, et al. Discovery of a Nur77-mediated cytoplasmic vacuolation and paraptosis inducer (4-PQBH) for the treatment of hepatocellular carcinoma. Bioorg Chem. 2022 Apr;121:105651. DOI:10.1016/j.bioorg.2022.105651
Benzoic acid, 4-(4-quinolinylamino)-, 2-(4-pyridinylmethylene)hydrazide Preparation Products And Raw materials
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