5H-Pyrimido[4,5-e][1,4]diazepin-5-one, 2-(ethylamino)-6,7,8,9-tetrahydro-9-methyl-6-[3-[(1S)-3-(methylamino)-1-(2-thienyl)propoxy]phenyl]-

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5H-Pyrimido[4,5-e][1,4]diazepin-5-one, 2-(ethylamino)-6,7,8,9-tetrahydro-9-methyl-6-[3-[(1S)-3-(methylamino)-1-(2-thienyl)propoxy]phenyl]- Suppliers list
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5H-Pyrimido[4,5-e][1,4]diazepin-5-one, 2-(ethylamino)-6,7,8,9-tetrahydro-9-methyl-6-[3-[(1S)-3-(methylamino)-1-(2-thienyl)propoxy]phenyl]- manufacturers
5H-Pyrimido[4,5-e][1,4]diazepin-5-one, 2-(ethylamino)-6,7,8,9-tetrahydro-9-methyl-6-[3-[(1S)-3-(methylamino)-1-(2-thienyl)propoxy]phenyl]- Basic information
Product Name:5H-Pyrimido[4,5-e][1,4]diazepin-5-one, 2-(ethylamino)-6,7,8,9-tetrahydro-9-methyl-6-[3-[(1S)-3-(methylamino)-1-(2-thienyl)propoxy]phenyl]-
Synonyms:5H-Pyrimido[4,5-e][1,4]diazepin-5-one, 2-(ethylamino)-6,7,8,9-tetrahydro-9-methyl-6-[3-[(1S)-3-(methylamino)-1-(2-thienyl)propoxy]phenyl]-;Cavα2δ1&NET-IN-3
CAS:2143584-82-9
MF:C24H30N6O2S
MW:466.6
EINECS:
Product Categories:
Mol File:2143584-82-9.mol
5H-Pyrimido[4,5-e][1,4]diazepin-5-one, 2-(ethylamino)-6,7,8,9-tetrahydro-9-methyl-6-[3-[(1S)-3-(methylamino)-1-(2-thienyl)propoxy]phenyl]- Structure
5H-Pyrimido[4,5-e][1,4]diazepin-5-one, 2-(ethylamino)-6,7,8,9-tetrahydro-9-methyl-6-[3-[(1S)-3-(methylamino)-1-(2-thienyl)propoxy]phenyl]- Chemical Properties
Boiling point 682.8±65.0 °C(Predicted)
density 1.252±0.06 g/cm3(Predicted)
pka9.73±0.10(Predicted)
Safety Information
MSDS Information
5H-Pyrimido[4,5-e][1,4]diazepin-5-one, 2-(ethylamino)-6,7,8,9-tetrahydro-9-methyl-6-[3-[(1S)-3-(methylamino)-1-(2-thienyl)propoxy]phenyl]- Usage And Synthesis
UsesCavα2δ1&NET-IN-3 (example 216) is an inhibitor of the subunit α2δ of voltage-gated calcium channels (VGCC) and noradrenaline transporter (NET). Cavα2δ1&NET-IN-3 has Kis of 100-500 nM for human α2δ-1 subunit of Cav2.2 calcium channel and NET, respectively[1].
IC 50Calcium Channel
References[1] Félix CUEVAS-CORDOBéS, et al. Tetrahydropyrimidodiazepine and tetrahydropyridodiazepine compounds for treating pain and pain related conditions. WO2017191304A1.
5H-Pyrimido[4,5-e][1,4]diazepin-5-one, 2-(ethylamino)-6,7,8,9-tetrahydro-9-methyl-6-[3-[(1S)-3-(methylamino)-1-(2-thienyl)propoxy]phenyl]- Preparation Products And Raw materials
Tag:5H-Pyrimido[4,5-e][1,4]diazepin-5-one, 2-(ethylamino)-6,7,8,9-tetrahydro-9-methyl-6-[3-[(1S)-3-(methylamino)-1-(2-thienyl)propoxy]phenyl]-(2143584-82-9) Related Product Information
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