印苦楝内酯
| 中文名称 | 印苦楝内酯 |
|---|---|
| 中文同义词 | 印苦楝内酯;宁波利特;奈博德;NIMBOLIDE,CYCLINA AND ERK1/2抑制剂;印苦楝内酯,10 MM DMSO 溶液;(2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-(3-呋喃基)-2a,5a,6,6a,8,9,9a,10a,10b,10c-十氢-2a,5a,6a,7-四甲基-2,5-二氧代-2H,5H-环戊并[d']萘并[1,8-bc:2,3-b']二呋喃-6-乙酸甲酯;印苦楝内酯Nimbolide;印苦楝内酯Nimbolide |
| 英文名称 | nimbolide |
| 英文同义词 | nimbolide;(17R)-7α,15β:21,23-Diepoxy-6α-hydroxy-4,8-dimethyl-1-oxo-11-methoxycarbonyl-18,24-dinor-11,12-seco-5α-chola-2,13,20,22-tetrene-4α-carboxylic acid γ-lactone;NSC 309909;2H,5H-Cyclopenta[d']naphtho[1,8-bc:2,3-b']difuran-6-acetic acid, 8-(3-furanyl)-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2a,5a,6a,7-tetramethyl-2,5-dioxo-, methyl ester, (2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-;methyl [(2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-furan-3-yl-2a,5a,6a,7-tetramethyl-2,5-dioxo-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2H,5H-cyclopenta[d]naphtho[2,3-b:1,8-b''c'']difuran-6-yl]acetate;Nimbolide (25 mg);Nimbolide, CyclinA and ERK1/2 inhibitor;Nimbolide, 10 mM in DMSO |
| CAS号 | 25990-37-8 |
| 分子式 | C27H30O7 |
| 分子量 | 466.52 |
| EINECS号 | |
| 相关类别 | 化工原料;天然植物分子;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 25990-37-8.mol |
| 结构式 |  |
印苦楝内酯 性质
| 熔点 | >223°C (dec.) |
|---|---|
| 沸点 | 608.6±55.0 °C(Predicted) |
| 密度 | 1.32±0.1 g/cm3(Predicted) |
| 储存条件 | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| 溶解度 | 可溶于氯仿、乙酸乙酯 |
| 形态 | 粉末 |
| 颜色 | 浅米色至黄色 |
| 主要应用 | metabolomics vitamins, nutraceuticals, and natural products |
| InChIKey | KMTFKEPRKBPCJW-UHFFFAOYSA-N |
| SMILES | C12C3(C)C=CC(=O)C1(C)C(CC(=O)OC)C1(C)C4C(C(C=C4C)C4=COC=C4)OC1C2OC3=O |
Nimbolide 是一种源自 Azadirachta indica L 叶和花的三萜化合物。Nimbolide 通过抑制 NF-κB 而诱导肿瘤细胞凋亡。 Nimbolide 抑制 CDK4/CDK6 激酶活性。Nimbolide 抑制 NF-κB，Wnt，PI3K-Akt，MAPK 和 JAK-STAT 信号通路。
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NF-κB
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CDK4
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CDK6
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用途
Nimbolide, a natural triterpenoid present in the edible parts of the neem tree (Azadirachta indica), was found to be growth-inhibitory in human colon carcinoma HT-29 cells. Nimbolide treatment of cell s at 2.5 - 10 μM resulted in moderate to very strong growth inhibition.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| RTECS号 | GY2370000 |
| 存储类别 | 11 - 可燃固体 |
| 危险性类别 | 急性毒性 类别4 经口 |
| 毒性 | hamster,LD50,intraperitoneal,> 500mg/kg (500mg/kg),Toxicology Letters. Vol. 30, Pg. 159, 1986. |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-116035 | 印苦楝内酯 Nimbolide | 25990-37-8 | 1mg | 929元 |
| 2025/12/22 | HY-116035 | 印苦楝内酯 Nimbolide | 25990-37-8 | 5mg | 2323元 |