- Echinatin
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- $31.00 / 1mg
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2026-04-22
- CAS:34221-41-5
- Min. Order:
- Purity: 98.36%
- Supply Ability: 10g
- Echinatin
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- $0.00 / 5mg
-
2023-02-24
- CAS:34221-41-5
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
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| | 4,4'-DIHYDROXY-2-METHOXYCHALCONE Basic information |
| | 4,4'-DIHYDROXY-2-METHOXYCHALCONE Chemical Properties |
| Melting point | 210°C (dec.) | | Boiling point | 509.8±50.0 °C(Predicted) | | density | 1.282±0.06 g/cm3 (20 ºC 760 Torr) | | storage temp. | 2-8°C | | solubility | DMSO : 250 mg/mL (924.97 mM; Need ultrasonic) | | form | powder | | pka | 7.82±0.15(Predicted) | | color | Orange | | Major Application | food and beverages | | InChI | InChI=1S/C16H14O4/c1-20-16-10-14(18)8-4-12(16)5-9-15(19)11-2-6-13(17)7-3-11/h2-10,17-18H,1H3/b9-5+ | | InChIKey | QJKMIJNRNRLQSS-WEVVVXLNSA-N | | SMILES | C(C1=CC=C(O)C=C1)(=O)/C=C/C1=CC=C(O)C=C1OC |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | 4,4'-DIHYDROXY-2-METHOXYCHALCONE Usage And Synthesis |
| Chemical Properties | White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from licorice root. | | Uses | Echinatin is used as an anticancer agent inhibiting DNA topoisomerase IB and Tyrosyl-DNA phosphodiesterase 1 inhibitors. | | in vivo | Echinatin (20 and 40 mg/kg, i.p.) inhibits LPS-induced septic shock in mice by inhibiting NLRP3 inflammasome activation[2].
Echinatin (20-80 mg/kg, i.p.) shows cardioprotective effect, and relieves I/R-Induced Myocardial Injury in rats[3].
Echinatin (20 and 50mg/kg, p.o.) inhibits tumor growth and inhibits the AKT/mTOR pathway of KYSE270-derived tumor mice xenografts[4].
| Animal Model: | LPS-induced septic shock in mice[1] | | Dosage: | 20 and 40 mg/kg | | Administration: | i.p. | | Result: |
Inhibited LPS-induced IL-1β and TNF-α production.
Reduced the proportion and the number of neutrophils in peritoneal lavage cells from mice. |
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| | 4,4'-DIHYDROXY-2-METHOXYCHALCONE Preparation Products And Raw materials |
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