tubulin polymerization inhibitor
| 中文名称 | tubulin polymerization inhibitor |
|---|---|
| 中文同义词 | 化合物 TUBULIN POLYMERIZATION-IN-24 |
| 英文名称 | tubulin polymerization inhibitor |
| 英文同义词 | tubulin polymerization inhibitor;9(10H)-Anthracenone, 10-[(3-hydroxy-4-methoxyphenyl)methylene]-;Tubulin polymerization-IN-24 |
| CAS号 | 564468-51-5 |
| 分子式 | C22H16O3 |
| 分子量 | 328.36 |
| EINECS号 | |
| 相关类别 | A low molecular weight, cell-permeable, benzylidene-anthracenone antimicrotubule agent that exhibits potent antitumor activity. |
| Mol文件 | 564468-51-5.mol |
| 结构式 |  |
tubulin polymerization inhibitor 性质
| 储存条件 | -20°C |
|---|---|
| 溶解度 | DMSO: soluble 34mg/mL |
| 形态 | solid |
| InChI | 1S/C22H16O3/c1-25-21-11-10-14(13-20(21)23)12-19-15-6-2-4-8-17(15)22(24)18-9-5-3-7-16(18)19/h2-13,23H,1H3 |
| InChIKey | MQLACMBJVPINKE-UHFFFAOYSA-N |
| SMILES | COc1ccc(cc1O)\C=C2\c3ccccc3C(=O)c4ccccc24 |
Tubulin aggregation-IN-24 (compound HMBA) 是一种有效的tubulin aggregation 抑制剂。Tubulin aggregation-IN-24 抑制 MCF-7 细胞增殖。Tubulin aggregation-IN-24 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 G2/M 期。Tubulin aggregation-IN-24 增加 GTP 水解速率并抑制微管组装。
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |