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| Product Name: | S 2238 | | Synonyms: | S 2238;Chromogenic substrate S-2238;D-Phenylalanyl-L-2-piperidinecarbonyl-N-(4-nitro phenyl)-L-argininamide;H-D-Phenylalanyl-L-pipecolyl-arginine-nitroanilide;H-D-Phenylalanyl-pip-Arg-p-nitroanilide;H-Phe-pip-Arg-pna;H-Phe-pip-Arg-p-nitroanilide;Thrombin Substrate S2238 1 mg | | CAS: | 64815-81-2 | | MF: | C27H36N8O5 | | MW: | 552.63 | | EINECS: | | | Product Categories: | | | Mol File: | 64815-81-2.mol |  |
| | S 2238 Chemical Properties |
| density | 1.405±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | solubility | DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly, Sonicated) | | form | Solid | | pka | 13.291±0.20(predicted) | | color | White to Off-White | | Stability: | Hygroscopic |
| | S 2238 Usage And Synthesis |
| Uses | H-D-Phe-Pip-Arg-pNA (S-2238), a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA is sensitive, accurate, and easy to perform[1][2]. | | References | [1] Goodnight SH Jr, et al. Measurement of antithrombin III in normal and pathologic states using chromogenic substrate S-2238. Comparison with immunoelectrophoretic and factor Xa inhibition assays. Am J Clin Pathol. 1980;73(5):639-647. DOI:10.1093/ajcp/73.5.639
[2] Voorthuizen H, Kluft C. Improved assay conditions for automated antithrombin III determinations with the chromogenic substrate S-2238. Thromb Haemost. 1984;52(3):350-353. PMID:6531759 |
| | S 2238 Preparation Products And Raw materials |
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