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| | conantokin R Basic information |
| Product Name: | conantokin R | | Synonyms: | conantokin R;PubChem ID: 90488802;L-Proline, glycyl-L-α-glutamyl-4-carboxy-L-α-glutamyl-4-carboxy-L-α-glutamyl-L-valyl-L-alanyl-L-lysyl-L-methionyl-L-alanyl-L-alanyl-4-carboxy-L-α-glutamyl-L-leucyl-L-alanyl-L-arginyl-4-carboxy-L-α-glutamyl-L-asparaginyl-L-isoleucyl-L-alanyl-L-lysylglycyl-L-cysteinyl-L-lysyl-L-valyl-L-asparaginyl-L-c...;L-Proline, glycyl-L-α-glutamyl-4-carboxy-L-α-glutamyl-4-carboxy-L-α-glutamyl-L-valyl-L-alanyl-L-lysyl-L-methionyl-L-alanyl-L-alanyl-4-carboxy-L-α-glutamyl-L-leucyl-L-alanyl-L-arginyl-4-carboxy-L-α-glutamyl-L-asparaginyl-L-isoleucyl-L-alanyl-L-lysylglycyl-L-cysteinyl-L-lysyl-L-valyl-L-asparaginyl-L-cysteinyl-L-tyrosyl-, cyclic (21→25)-disulfide | | CAS: | 202925-60-8 | | MF: | C127H201N35O49S3 | | MW: | 3098.36 | | EINECS: | | | Product Categories: | | | Mol File: | 202925-60-8.mol |  |
| | conantokin R Chemical Properties |
| density | 1.56±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | Powder | | Sequence | Gly-Glu-{Gla}-{Gla}-Val-Ala-Lys-Met-Ala-Ala-{Gla}-Leu-Ala-Arg-{Gla}-Asn-Ile-Ala-Lys-Gly-Cys-Lys-Val-Asn-Cys-Tyr-Pro (Disulfide bridge:Cys21-Cys25) |
| | conantokin R Usage And Synthesis |
| Description | Potent, non-competitive NMDA receptor antagonist (IC50= 93 nM) that has been suggested to have NR2 subunit selectivity. Inhibits inward currents evoked by NMDA in central nervous system neurons (IC50= 350 nM) and exhibits broad anticonvulsant and antiparkinsonian activityin vivoat doses devoid of behavioral toxicity. | | Uses | Conantokin R (Con-R) is an NMDA receptor peptide antagonist with an IC50 of 93 nM. Conantokin R binds Zn2+ and Mg2+ with Kds of 0.15 μM and 6.5 μM, respectively. Conantokin R shows anticonvulsant activity[1][2]. | | References | [1] Blandl T, et al. Structure-function relationships of the NMDA receptor antagonist peptide, conantokin-R. FEBS Lett. 2000 Mar 24;470(2):139-46. DOI:10.1016/s0014-5793(00)01309-0
[2] White HS, et al. In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus. J Pharmacol Exp Ther. 2000 Jan;292(1):425-32. PMID:10604979 |
| | conantokin R Preparation Products And Raw materials |
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