DUP 105
| 中文名称 | DUP 105 |
|---|---|
| 中文同义词 | 化合物 T11123;化合物DUP 105;化合物DUP 105,10 MM DMSO 溶液 |
| 英文名称 | 4-methylsulfinylphenyloxooxazolidinylmethylacetamide |
| 英文同义词 | 4-methylsulfinylphenyloxooxazolidinylmethylacetamide;(5S)-5-Acetylaminomethyl-3-(4-methylsulfinylphenyl)oxazolidin-2-one;DuP-105;N-[[(5S)-3-[4-(Methylsulfinyl)phenyl]-2-oxooxazolidin-5-yl]methyl]acetamide;(S)-N-<<3-<4(S)-(methylsulfinyl)phenyl>-2-oxo-5-oxazolidinyl>methyl>acetamide;Acetamide, N-[[(5S)-3-[4-(methylsulfinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-;DuP 105, 10 mM in DMSO;N-[[(5S)-3-(4-Methylsulfinylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide |
| CAS号 | 96800-41-8 |
| 分子式 | C13H16N2O4S |
| 分子量 | 296.34 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 96800-41-8.mol |
| 结构式 |  |
DUP 105 性质
| 熔点 | 185.1-185.8 °C |
|---|---|
| 沸点 | 574.393±33.00 °C(Press: 760.00 Torr)(predicted) |
| 密度 | 1.403±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | Solid |
| 酸度系数(pKa) | 15.527±0.46(predicted) |
| 颜色 | White to off-white |
DuP 105 是一种可口服的恶唑烷酮类化合物，能够抗葛兰素阳性菌。
DuP 105 shows inhibitory activities against staphylococcal isolates and B. fragilis isolates with MIC 90 s of 4 to 16 μg/mL and 16 μg/mL. DuP 105 MICs for 50% of the 216 gram-positive isolates tested (MIC 50 s) range from 4.0 to 16 μg/mL.
DuP 105 administered by either the oral or the parenteral route is protective against staphylococcal and streptococcal infections in mice with the 50% effective doses of 9 to 23 mg/kg.