| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:T-1-PMPA
CAS:1323883-62-0
Package:50mg;10mg
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| | 1H-Purine-1-acetamide, 2,3,6,7-tetrahydro-3,7-dimethyl-N-(4-methylphenyl)-2,6-dioxo- Basic information |
| Product Name: | 1H-Purine-1-acetamide, 2,3,6,7-tetrahydro-3,7-dimethyl-N-(4-methylphenyl)-2,6-dioxo- | | Synonyms: | 1H-Purine-1-acetamide, 2,3,6,7-tetrahydro-3,7-dimethyl-N-(4-methylphenyl)-2,6-dioxo-;T-1-PMPA | | CAS: | 1323883-62-0 | | MF: | C16H17N5O3 | | MW: | 327.34 | | EINECS: | | | Product Categories: | | | Mol File: | 1323883-62-0.mol |  |
| | 1H-Purine-1-acetamide, 2,3,6,7-tetrahydro-3,7-dimethyl-N-(4-methylphenyl)-2,6-dioxo- Chemical Properties |
| density | 1.38±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | form | Solid | | pka | 13.59±0.70(predicted) | | color | White to off-white |
| | 1H-Purine-1-acetamide, 2,3,6,7-tetrahydro-3,7-dimethyl-N-(4-methylphenyl)-2,6-dioxo- Usage And Synthesis |
| Uses | T-1-PMPA is a potent EGFR inhibitor with apoptotic properties. T-1-PMPA effectively inhibits EGFRWT and EGFR790m, with IC50 values of 86 nM and 561.73 nM, respectively[1]. | | IC 50 | EGFRWT: 86 nM (IC50); EGFRT790M: 561.73 nM (IC50) | | References | [1] Ibrahim H Eissa, et al. New Theobromine Apoptotic Analogue with Anticancer Potential Targeting the EGFR Protein: Computational and In Vitro Studies. ACS Omega. 2024 Mar 27;9(14):15861-15881. DOI:10.1021/acsomega.3c08148 |
| | 1H-Purine-1-acetamide, 2,3,6,7-tetrahydro-3,7-dimethyl-N-(4-methylphenyl)-2,6-dioxo- Preparation Products And Raw materials |
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