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| | ELQ-598 Basic information |
| | ELQ-598 Chemical Properties |
| Boiling point | 580.7±50.0 °C(predicted) | | density | 1.327±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | pka | 5.06±0.50(predicted) |
| | ELQ-598 Usage And Synthesis |
| Uses | ELQ-598, as a prodrug, is converted into the active drug ELQ-596 upon oral administration. ELQ-598 demonstrates potent parasitic growth inhibition capabilities (IC50= 37 nM). ELQ-598 also shows low toxicity towards human cells (IC50= 19 μM). ELQ-598 can be used for research into babesiosis[1]. | | in vivo | ELQ-598 (10 mg/kg; p.o.; daily DPI 3-7) achieves complete elimination of B. duncaniinfection in C3H mice[1].
ELQ-598 (10 mg/kg; p.o.; daily DPI 3-7) is effective at eliminating B. microtiinfection in mice[1].
ELQ-598 (10 mg/kg; p.o.; daily DPI 3-7) combined with atovaquone (HY-13832) can eliminative of the infection in the C3H/HeJ mice infected with B. duncani and SCID mice model infected with B. microti[1].
| Animal Model: | C3H mice genetically prone to B. duncani infection[1] | | Dosage: | 10mg/kg | | Administration: | p.o.; daily DPI 3-7 | | Result: | Resulted in a complete elimination of the parasites. Mice survived for the duration of the study with no recurrence of parasitemia observed. |
| Animal Model: | C3H/HeJ mice for B. duncani infection, and SCID mice for B. microti infection[1] | | Dosage: | 10mg/kg with 10mg/kg atovaquone, | | Administration: | p.o.; daily DPI 3-7 | | Result: | All mice survived without any recurrence of parasitemia.
A potent synergistic or additive effect of the drug combination in eradicating the lethal infection.This combination strategy offers enhanced efficacy compared to the use of either compound alone. |
| | References | [1] Vydyam P, et al. Effectiveness of Two New Endochin-like Quinolones, ELQ-596 and ELQ-650, in Experimental Mouse Models of Human Babesiosis. ACS Infect Dis. 2024 Apr 12;10(4):1405-1413. DOI:10.1021/acsinfecdis.4c00143 |
| | ELQ-598 Preparation Products And Raw materials |
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