RapaBlock

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RapaBlock Basic information
Product Name:RapaBlock
Synonyms:RapaBlock;15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-[3-(1-oxido-2-pyridinyl)propyl]-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
CAS:2474076-02-1
MF:C49H74N2O13
MW:899.12
EINECS:
Product Categories:
Mol File:2474076-02-1.mol
RapaBlock Structure
RapaBlock Chemical Properties
Boiling point 987.640±75.00 °C(Press: 760.00 Torr)(predicted)
density 1.272±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka9.966±0.70(predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
RapaBlock Usage And Synthesis
UsesRapaBlock is a potent, non-immunosuppressive and brain-impermeable FKBP12 ligand[1].
References[1] Ziyang Zhang, et al. Brain-restricted mTOR inhibition with binary pharmacology. Nature. 2022 Sep;609(7928):822-828. DOI:10.1038/s41586-022-05213-y
RapaBlock Preparation Products And Raw materials
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