Thalidomide-NH-amido-C8-NH2

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Thalidomide-NH-amido-C8-NH2 Basic information
Product Name:Thalidomide-NH-amido-C8-NH2
Synonyms:Thalidomide-NH-amido-C8-NH2;Acetamide, N-(8-aminooctyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
CAS:2983057-93-6
MF:C23H31N5O5
MW:457.52
EINECS:
Product Categories:
Mol File:2983057-93-6.mol
Thalidomide-NH-amido-C8-NH2 Structure
Thalidomide-NH-amido-C8-NH2 Chemical Properties
Boiling point 779.4±60.0 °C(predicted)
density 1.309±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka10.73±0.40(predicted)
Safety Information
MSDS Information
Thalidomide-NH-amido-C8-NH2 Usage And Synthesis
UsesThalidomide-NH-amido-C8-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
IC 50Cereblon
References[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277
Thalidomide-NH-amido-C8-NH2 Preparation Products And Raw materials
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