3-Pyridinecarboxamide, N-[3-(aminosulfonyl)phenyl]-2-(4,4-difluoro-1-piperidinyl)-5-(trifluoromethyl)-

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3-Pyridinecarboxamide, N-[3-(aminosulfonyl)phenyl]-2-(4,4-difluoro-1-piperidinyl)-5-(trifluoromethyl)- Basic information
Product Name:3-Pyridinecarboxamide, N-[3-(aminosulfonyl)phenyl]-2-(4,4-difluoro-1-piperidinyl)-5-(trifluoromethyl)-
Synonyms:3-Pyridinecarboxamide, N-[3-(aminosulfonyl)phenyl]-2-(4,4-difluoro-1-piperidinyl)-5-(trifluoromethyl)-;Nav1.8-IN-14
CAS:2417373-18-1
MF:C18H17F5N4O3S
MW:464.41
EINECS:
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Mol File:2417373-18-1.mol
3-Pyridinecarboxamide, N-[3-(aminosulfonyl)phenyl]-2-(4,4-difluoro-1-piperidinyl)-5-(trifluoromethyl)- Structure
3-Pyridinecarboxamide, N-[3-(aminosulfonyl)phenyl]-2-(4,4-difluoro-1-piperidinyl)-5-(trifluoromethyl)- Chemical Properties
density 1.56±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka9.94±0.60(predicted)
Safety Information
MSDS Information
3-Pyridinecarboxamide, N-[3-(aminosulfonyl)phenyl]-2-(4,4-difluoro-1-piperidinyl)-5-(trifluoromethyl)- Usage And Synthesis
UsesNav1.8-IN-14 (compound 20) is a potent and selective Nav1.8 inhibitor. Nav1.8-IN-14 can be used in the study of pain-related diseases[1].
References[1] Breslin MJ, et al. 2-Aminopyridines as Potent and Selective Nav1.8 Inhibitors Exhibiting Efficacy in a Nonhuman Primate Pain Model. ACS Med Chem Lett. 2024 May 24;15(6):917-923. DOI:10.1021/acsmedchemlett.4c00103
3-Pyridinecarboxamide, N-[3-(aminosulfonyl)phenyl]-2-(4,4-difluoro-1-piperidinyl)-5-(trifluoromethyl)- Preparation Products And Raw materials
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