Benzenesulfonamide, N-[2-(7-aminoheptyl)-1-(phenylmethyl)-1H-benzimidazol-5-yl]-2,4,6-trimethyl-

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Benzenesulfonamide, N-[2-(7-aminoheptyl)-1-(phenylmethyl)-1H-benzimidazol-5-yl]-2,4,6-trimethyl- Suppliers list
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Benzenesulfonamide, N-[2-(7-aminoheptyl)-1-(phenylmethyl)-1H-benzimidazol-5-yl]-2,4,6-trimethyl- Basic information
Product Name:Benzenesulfonamide, N-[2-(7-aminoheptyl)-1-(phenylmethyl)-1H-benzimidazol-5-yl]-2,4,6-trimethyl-
Synonyms:Benzenesulfonamide, N-[2-(7-aminoheptyl)-1-(phenylmethyl)-1H-benzimidazol-5-yl]-2,4,6-trimethyl-;JMV6944
CAS:2871774-93-3
MF:C30H38N4O2S
MW:518.72
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Mol File:2871774-93-3.mol
Benzenesulfonamide, N-[2-(7-aminoheptyl)-1-(phenylmethyl)-1H-benzimidazol-5-yl]-2,4,6-trimethyl- Structure
Benzenesulfonamide, N-[2-(7-aminoheptyl)-1-(phenylmethyl)-1H-benzimidazol-5-yl]-2,4,6-trimethyl- Chemical Properties
Boiling point 718.7±70.0 °C(predicted)
density 1.19±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka8.40±0.30(predicted)
Safety Information
MSDS Information
Benzenesulfonamide, N-[2-(7-aminoheptyl)-1-(phenylmethyl)-1H-benzimidazol-5-yl]-2,4,6-trimethyl- Usage And Synthesis
UsesJMV6944 is a PXR agonist. JMV6944 competitively inhibits hPXR ligand-binding domain (LBD) binding to PXR with an IC50 of 680nM. JMV6944 induces CYP3A4 mRNA expression in freshly isolated human primary human hepatocyte cultures. JMV6944 can be used for the synthesis of PROTAC PXR degrader JMV7048 (HY-162704)[1].
References[1] Bansard L, et al. A potent agonist-based PROTAC targeting Pregnane X Receptor that delays colon cancer relapse[J]. 2024.
Benzenesulfonamide, N-[2-(7-aminoheptyl)-1-(phenylmethyl)-1H-benzimidazol-5-yl]-2,4,6-trimethyl- Preparation Products And Raw materials
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