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TargetMol Chemicals Inc.
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15002134094 |
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marketing@targetmol.cn |
| Products Intro: |
Product Name:Imiquimod 2HCl
CAS:2995277-02-4
Purity:99.18% Package:1mg/RMB 1300;5mg/RMB 3250;10mg/RMB 4750
|
| Company Name: |
Shanghai Amole Biotechnology Co., Ltd.
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| Tel: |
18916360931 18916360931 |
| Email: |
2596183085@qq.com |
| Products Intro: |
Product Name:Imiquimod 2HCl
CAS:2995277-02-4
Purity:5mg；50mg；25mg；1mg；10mg；100mg Package:99%
|
Imiquimod 2HCl manufacturers
- Imiquimod 2HCl
-
- $195.00 / 1mg
-
2025-12-16
- CAS:2995277-02-4
- Min. Order:
- Purity: 99.41%
- Supply Ability: 10g
- Imiquimod 2HCl
-
- $195.00 / 1mg
-
2025-12-16
- CAS:2995277-02-4
- Min. Order:
- Purity: 99.41%
- Supply Ability: 10g
- Imiquimod 2HCl
-
- $195.00 / 1mg
-
2025-05-15
- CAS:2995277-02-4
- Min. Order:
- Purity: 99.18%
- Supply Ability: 10g
|
| | Imiquimod 2HCl Basic information |
| Product Name: | Imiquimod 2HCl | | Synonyms: | Imiquimod 2HCl;1H-Imidazo[4,5-c]quinolin-4-amine, 1-(2-methylpropyl)-, hydrochloride (1:2) | | CAS: | 2995277-02-4 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Imiquimod 2HCl Structure]() |
| | Imiquimod 2HCl Chemical Properties |
| | Imiquimod 2HCl Usage And Synthesis |
| Uses | Imiquimod (R 837) dihydrochloride, an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod exhibits antiviral and antitumor effects in vivo. Imiquimod can be used for the research of external genital, perianal warts, cancer and COVID-19[1][2]. | | in vivo | Imiquimod (IMQ) can be used to induce psoriasis models[5].
Induction of psoriasis Model[5] Background
Lmiquimod (IMQ) induces inflamed scaly skin lesions resembling plaque-type psoriasis. IMQ induces epidermal expression of IL-23, IL-17A, and IL-17F, as well as an increase in splenic Th17 cells.
Specific Mmodeling Methods
Mice: BALB/c ? male ? 8-week-old
Administration: 3.125 mg/day ? skin ? 6 days
Note
IMQ cream preparation [7]:
(1) Prepare BM of lipids
STA and OA were melted at 75 °C followed by the addition of IMQ (3.5% of the BM, w/w) under continuous stirring.
Polysorbate 80 and stearoyl polyoxyl-32 glycerides at a 50:50 ratio were dispersed in water heated separately to 75 °C and added to the BM phase under continuous stirring.
(2) Prepare nanostructured lipid carriers (NLCs)
The mixture was then subjected to high-shear homogenization followed by ultrasonication.
The mixture was then rapidly cooled in an ice bath to allow the formation of NLCs.
Modeling Indicators Behavior Observation: Induced
the back skin of the mice started to display signs of erythema, scaling, and
thickening.
Resulted in hyperproliferative keratinocytes and a
disturbed epidermal differentiation (parakeratosis).
Correlated Product(s): / Opposite Product(s): / . | | References | [1] Athina Angelopoulou, et al. Imiquimod - A toll like receptor 7 agonist - Is an ideal option for management of COVID 19. Environ Res. 2020 Sep; 188: 109858. DOI:10.1016/j.envres.2020.109858
[2] Aditya K Gupta, et al. Imiquimod: a review. J Cutan Med Surg. Nov-Dec 2002;6(6):554-60. DOI:10.1007/s10227-001-0134-6
[3] Yuji Kan, et al. Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway. J Virol. 2012 Oct;86(19):10338-46. DOI:10.1128/JVI.01196-12
[4] Michael P Sch?n, et al. The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7- and TLR8-independent fashion. J Invest Dermatol. 2006 Jun;126(6):1338-47. DOI:10.1038/sj.jid.5700286
[5] Leslie van der Fits, et al. Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. J Immunol. 2009, 182, 9. DOI:10.4049/jimmunol.0802999
[6] Ajla Smajlovi?, et al. Molecular and histopathological profiling of imiquimod induced dermatosis in Swiss Wistar rats: contribution to the rat model for novel anti-psoriasis treatments. Mol Biol Rep. 2021, 48, 5. DOI:10.1007/s11033-021-06445-3
[7] Sangseo Kim, et al. Development and Optimization of Imiquimod-Loaded Nanostructured Lipid Carriers Using a Hybrid Design of Experiments Approach. Int J Nanomedicine. 2023. DOI:10.2147/IJN.S400610 |
| | Imiquimod 2HCl Preparation Products And Raw materials |
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