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| | 2,3-Difluoropyridine-4-carboxylic acid Basic information |
| Product Name: | 2,3-Difluoropyridine-4-carboxylic acid | | Synonyms: | 2,3-Difluoropyridine-4-carboxylic acid;4-Pyridinecarboxylic acid, 2,3-difluoro-;2,3-Difluoropyridine-4-carboxylic acid, 4-Carboxy-2,3-difluoropyridine;2,3-Difluoro-4-carboxypyridine;2,3-Fifluoroisonicotinic acid;2,3-difluoro-4-pyridinecarboxylic acid;2,3-Difluoroisonicotinic acid;2,3-Difluoroisonicotinic acid 97% | | CAS: | 851386-31-7 | | MF: | C6H3F2NO2 | | MW: | 159.09 | | EINECS: | 214-589-6 | | Product Categories: | Fluorine series | | Mol File: | 851386-31-7.mol |  |
| | 2,3-Difluoropyridine-4-carboxylic acid Chemical Properties |
| Melting point | 159-160 °C | | Boiling point | 377.4±37.0 °C(Predicted) | | density | 1.535 | | storage temp. | 2-8°C | | solubility | soluble in Methanol | | form | powder to crystal | | pka | 2.10±0.10(Predicted) | | color | White to Orange to Green | | InChI | 1S/C6H3F2NO2/c7-4-3(6(10)11)1-2-9-5(4)8/h1-2H,(H,10,11) | | InChIKey | FFGHMEKFPCGYEG-UHFFFAOYSA-N | | SMILES | OC(=O)c1ccnc(F)c1F | | CAS DataBase Reference | 851386-31-7 |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 2933399990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | 2,3-Difluoropyridine-4-carboxylic acid Usage And Synthesis |
| Uses | 2,3-Difluoropyridine-4-carboxylic acid is particularly important as starting materials for agrochemicals and pharmaceuticals. | | Synthesis | To a solution of n-BuLi (26.1 mL, 52.09 mmol) in THF (70 mL, Na distilled) was added N,N-diisopropylamine (7.30 mL, 52.09 mmol) and 2,3-difluoropyridine (5.00 g, 43.41 mmol) successively at -78 C. The resulting mixture was stirred at -78C for 1 hour and then poured over crushed dry ice (excess). The reaction was allowed to warm up to room temperature for 1 h and after evaporation of the excess dry ice and THF, the residue was added to water (100 mL) and washed with EtOAc (2 x 50 mL). The aqueous layer was then acidified to pH
1 and extracted with EtOAc (2 x 100 mL). The combined organic extracts were dried and evaporated to give the product 2,3-difluoropyridine-4-carboxylic acid. Yield = 2.39 g, 35%. |
| | 2,3-Difluoropyridine-4-carboxylic acid Preparation Products And Raw materials |
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