6-Bromo-2-pyridyl p-tolyl ketone

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6-Bromo-2-pyridyl p-tolyl ketone Basic information
Product Name:6-Bromo-2-pyridyl p-tolyl ketone
Synonyms:2-Bromo-6-(4-methylbenzoyl) pyridine;(6-Bromopyridin-2-yl)(p-tolyl)methanone;Methanone, (6-bromo-2-pyridinyl)(4-methylphenyl)-;(6-Bromo-2-pyridinyl)(4-methylphenyl)methanone;6-Bromo-2-pyridyl p-tolyl ketone
CAS:87848-95-1
MF:C13H10BrNO
MW:276.13
EINECS:618-079-0
Product Categories:
Mol File:87848-95-1.mol
6-Bromo-2-pyridyl p-tolyl ketone Structure
6-Bromo-2-pyridyl p-tolyl ketone Chemical Properties
Melting point 97-98 °C(Solv: ethanol (64-17-5); water (7732-18-5))
Boiling point 411.3±35.0 °C(Predicted)
density 1.53 at 20℃
vapor pressure 0.002Pa at 25℃
form Solid:crystalline
pka0.32±0.10(Predicted)
LogP3.6 at 25℃ and pH7
Surface tension72.5mN/m at 5.5mg/L and 20℃
Safety Information
MSDS Information
6-Bromo-2-pyridyl p-tolyl ketone Usage And Synthesis
Uses(6-Bromopyridin-2-yl)(p-tolyl)methanone is an intermediate used in the synthesis of acrivastine; an antihistamine drug.
6-Bromo-2-pyridyl p-tolyl ketone Preparation Products And Raw materials
Raw materialsp-Tolunitrile-->4-Chlorobenzoic acid-->2,6-Dibromopyridine-->Iodomethane-->sec-Butyllithium
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