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| | Cyclosporine Basic information |
| Product Name: | Cyclosporine | | Synonyms: | (3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]cyclo(L-Leu-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-L-Val-);Cyclosporin A, 5-L-valine- | | CAS: | 63798-73-2 | | MF: | C61H109N11O12 | | MW: | 1188.61 | | EINECS: | | | Product Categories: | Organics | | Mol File: | 63798-73-2.mol |  |
| | Cyclosporine Chemical Properties |
| Boiling point | 1306.2±65.0 °C(Predicted) | | density | 1.017±0.06 g/cm3(Predicted) | | pka | 13.38±0.70(Predicted) |
| | Cyclosporine Usage And Synthesis |
| Uses | Cyclosporin E (11-Demethylcyclosporin A) is a cyclic oligopeptide that can be isolated from fungi such as TTrichoderma polysporum and other imperfect fungi. Cyclosporin E belongs to the Cyclosporins family. Cyclosporin E can be used for studying the structure-activity relationships and molecular dynamic properties of cyclosporin compounds. As a structural control compound, Cyclosporin E holds significant research value in the fields of medicinal chemistry and biophysics[1][2]. | | References | [1] Traber R, et al. Neue Cyclopeptide aus Trichoderma polysporum (LINK EX PERS.) RIFAI: die Cyclosporine B, D und E [New cyclopeptides from Trichoderma polysporum (Link ex Pers.) Rifai: cyclosporins B, D and E (author's transl)]. Helv Chim Acta. 1977;60(5):1568-78. German. DOI:10.1002/hlca.19770600513
[2] Kobchikova P P, et al. Features of spatial structures of cyclosporins D, E and G revealed by NMR and MD simulations[J]. Journal of Molecular Liquids, 2021, 336: 116244. |
| | Cyclosporine Preparation Products And Raw materials |
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